Cheshire P J
Br J Cancer. 1970 Sep;24(3):542-7. doi: 10.1038/bjc.1970.65.
Spontaneous and transplanted tumour growth rates studied in the C3H mouse have shown that when only one spontaneous tumour was present in one strain then the distribution of growth rates closely resembled that for first generation isotransplants of another strain. It was also shown that the number of spontaneous tumours (in the range one to four tumours) present on the mouse affected the tumour growth rate, i.e. the more tumours per mouse, the slower the growth rate of the earliest tumour. This factor might partly account for the discrepancy between human tumour growth rates (normally determined when many tumours are present in the patients) and the faster tumour growth rates observed in experimental animals, in which normally only single tumours are present.
在C3H小鼠中对自发肿瘤和移植肿瘤生长速率的研究表明，当一个品系中仅存在一个自发肿瘤时，其生长速率分布与另一品系第一代同基因移植肿瘤的生长速率分布极为相似。研究还表明，小鼠身上存在的自发肿瘤数量（在1至4个肿瘤范围内）会影响肿瘤生长速率，即每只小鼠的肿瘤越多，最早出现的肿瘤生长速率就越慢。这一因素可能部分解释了人类肿瘤生长速率（通常是在患者身上存在多个肿瘤时测定）与实验动物中观察到的较快肿瘤生长速率之间的差异，在实验动物中通常仅存在单个肿瘤。
