Shanoff H M, Little J A, Csima A
Can Med Assoc J. 1970 Oct 24;103(9):927-31.
The relation of serum cholesterol and standard S(t) lipoproteins to survival over a 10-year period was studied in a "good risk" group of 120 men, aged 31 to 83, who had survived myocardial infarction by at least three months. All subjects were free of other disorders that might affect survival and were not receiving therapy to alter their serum lipids.Ten-year survival from time of entry into the study was 35%. Age had no important influence on survival. Neither the level of the serum cholesterol nor of the lipoprotein fractions related to survival. Mode of coronary death, whether infarctional or sudden, was also unrelated to serum cholesterol.Although the incidence and age of onset of CHD is influenced by serum lipid levels, survival subsequent to infarction is not. Apparently serum lipids affect the rate of atherogenesis in the long silent preclinical stage, but in the short clinical stage other factors determine survival. This suggests that therapy to lower serum lipids, based on a specific diagnosis of the type of hyperlipoproteinemia, should be started early in life before clinical disease occurs.
对120名年龄在31至83岁之间、心肌梗死后存活至少三个月的“低风险”男性进行了研究，以探讨血清胆固醇和标准S(t)脂蛋白与10年生存期的关系。所有受试者均无其他可能影响生存的疾病，且未接受改变血脂的治疗。从进入研究开始计算，10年生存率为35%。年龄对生存率没有重要影响。血清胆固醇水平和脂蛋白组分均与生存率无关。冠状动脉死亡方式，无论是梗死性还是突发性，也与血清胆固醇无关。虽然冠心病的发病率和发病年龄受血脂水平影响，但梗死后的生存率并非如此。显然，血脂在漫长的无症状临床前期会影响动脉粥样硬化的发生速度，但在短暂的临床阶段，其他因素决定生存率。这表明，基于对高脂蛋白血症类型的特定诊断而进行的降低血脂治疗，应在临床疾病发生前尽早开始。
