Ellul-Micallef R, Fenech F F
Lancet. 1975 Dec 27;2(7948):1269-71. doi: 10.1016/s0140-6736(75)90608-x.
The beta effects of adrenergic stimulation are often diminished in asthmatics in whom the condition is active. Corticosteroids are thought to lower the threshold of beta-adrenergic receptors to the response of catecholamines. A single intravenous injection of 40 mg prednisolone appeared to restore responsiveness to inhaled isoprenaline in eight out of ten chronic asthmatics who were previously non-responsive to catecholamines.
在哮喘发作期患者中，肾上腺素能刺激的β效应常常减弱。皮质类固醇被认为可降低β肾上腺素能受体对儿茶酚胺反应的阈值。对10名先前对儿茶酚胺无反应的慢性哮喘患者单次静脉注射40mg泼尼松龙后，其中8名患者似乎恢复了对吸入异丙肾上腺素的反应性。
