静脉注射泼尼松龙对肾上腺素能反应性降低的哮喘患者的影响。
Effect of intravenous prednisolone in asthmatics with diminished adrenergic responsiveness.
作者信息
Ellul-Micallef R, Fenech F F
出版信息
Lancet. 1975 Dec 27;2(7948):1269-71. doi: 10.1016/s0140-6736(75)90608-x.
PMID:54795
Abstract
The beta effects of adrenergic stimulation are often diminished in asthmatics in whom the condition is active. Corticosteroids are thought to lower the threshold of beta-adrenergic receptors to the response of catecholamines. A single intravenous injection of 40 mg prednisolone appeared to restore responsiveness to inhaled isoprenaline in eight out of ten chronic asthmatics who were previously non-responsive to catecholamines.
摘要
在哮喘发作期患者中，肾上腺素能刺激的β效应常常减弱。皮质类固醇被认为可降低β肾上腺素能受体对儿茶酚胺反应的阈值。对10名先前对儿茶酚胺无反应的慢性哮喘患者单次静脉注射40mg泼尼松龙后，其中8名患者似乎恢复了对吸入异丙肾上腺素的反应性。
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