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来自一家蠕形螨病高发犬舍的健康幼犬对PHA-P的皮肤反应不足。

Deficient cutaneous response to PHA-P in healthy puppies from a kennel with a high prevalence of demodicosis.

作者信息

Wilkie B N, Markham R J, Hazlett C

出版信息

Can J Comp Med. 1979 Oct;43(4):415-9.

PMID:548162
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1320014/
Abstract

Intradermal injection of phytohemagglutinin was used to evaluate the integrity of cell-mediated immunological reactions in Doberman puppies thought to be predisposed to demodicosis. Results indicate a statistically significant deficiency of cutaneous delayed response in these dogs when compared with age matched Beagles, adult Dobermans or random control dogs of various ages and breeding. The high prevalence of demodicosis in the kennel of origin may have been due to the observed deficiency of cutaneous immune function.

摘要

采用皮内注射植物血凝素的方法,评估被认为易患蠕形螨病的杜宾幼犬细胞介导免疫反应的完整性。结果表明,与年龄匹配的比格犬、成年杜宾犬或不同年龄和品种的随机对照犬相比,这些犬的皮肤迟发性反应在统计学上存在显著不足。原犬舍中蠕形螨病的高发病率可能是由于观察到的皮肤免疫功能缺陷所致。

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引用本文的文献

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本文引用的文献

1
Cellular recognition by mouse lymphocytes in vitro. I. Definition of a new technique and results of stimulation by phytohemagglutinin and specific antigens.小鼠淋巴细胞在体外的细胞识别。I. 一种新技术的定义以及植物血凝素和特异性抗原刺激的结果。
J Exp Med. 1970 Jun 1;131(6):1049-78. doi: 10.1084/jem.131.6.1049.
2
Phytohemagglutinin skin test: a possible in vivo measure of cell-mediated immunity.
J Pediatr. 1972 Oct;81(4):775-80. doi: 10.1016/s0022-3476(72)80101-x.
3
Phytohemagglutinin (PHA) skin test in the diagnosis of cellular immunodeficiency.
J Allergy Clin Immunol. 1973 Jul;52(1):31-7. doi: 10.1016/0091-6749(73)90118-8.
4
Demodectic mange in dogs immunosuppressed with antilymphocyte serum.使用抗淋巴细胞血清免疫抑制的犬蠕形螨病。
Transplantation. 1972 Jun;13(6):616-7.
5
Suppression of in vitro lymphocyte transformation by serum from dogs with generalized demodicosis.全身性蠕形螨病犬血清对体外淋巴细胞转化的抑制作用。
Am J Vet Res. 1975 Nov;36(11):1591-5.
6
Age-related susceptibility to infection with canine distemper virus in gnotobiotic dogs.无菌犬中与年龄相关的犬瘟热病毒感染易感性
J Infect Dis. 1976 Dec;134(6):629-32. doi: 10.1093/infdis/134.6.629.
7
Intradermal mitogen response in dogs: correlation with outcome of infection by canine distemper virus.
Am J Vet Res. 1977 Oct;38(10):1539-42.
8
Immune mechanisms affecting bovine leucocytes during suppression of tuberculin skin sensitivity in cattle.牛结核菌素皮肤敏感性受抑制期间影响牛白细胞的免疫机制。
Int Arch Allergy Appl Immunol. 1976;52(1-4):3-14. doi: 10.1159/000231660.
9
Immunobiology of aging: evaluation of current status.衰老的免疫生物学:现状评估
Clin Immunol Immunopathol. 1976 Nov;6(3):394-413. doi: 10.1016/0090-1229(76)90093-3.
10
Cellular immune responsiveness in dogs with demodectic mange.患有蠕形螨病的犬的细胞免疫反应性。
Transplant Proc. 1975 Dec;7(4):557-9.