Vestergaard P, Amdisen A, Hansen H E, Schou M
Encephale. 1979;5(5 Suppl):633-9.
In our hospital, we are studying the renal function of more than 200 patients under lithium treatment. The glomerular function seems to be affected to a small extent, even by long-term lithium administration, and there have been no instances of progressive deterioration of renal function with azotemia. Most of the patients have impaired water reabsorption with polyuria and polydipsia. This is frequently combined with lowered concentrating ability. Polyuria and lowered concentrating ability are not in themselves life-threatening. However, development of dehydration may lead to lithium poisoning, and patients under lithium treatment should be advised to drink extra fluid under circumstances when the fluid balance may become negative. Further studies are required for definitive recommendations concerning extra monitoring of kidney function and lowering of lithium doses.
在我们医院，我们正在研究200多名接受锂治疗患者的肾功能。即使长期服用锂，肾小球功能似乎也只受到轻微影响，且没有出现肾功能进行性恶化伴氮质血症的情况。大多数患者存在水重吸收受损，伴有多尿和烦渴。这常与浓缩能力降低同时出现。多尿和浓缩能力降低本身并不危及生命。然而，脱水的发展可能导致锂中毒，对于接受锂治疗的患者，应建议在体液平衡可能变为负值的情况下额外补充液体。关于肾功能的额外监测和降低锂剂量的明确建议还需要进一步研究。
