Lambs L, Brion M, Berthon G
Agents Actions. 1984 Jun;14(5-6):743-50. doi: 10.1007/BF01978919.
The equilibria of the complexes formed separately by calcium and magnesium with tetracycline, oxytetracycline, doxycycline and minocycline were studied in the previous parts of this series. Computer simulations run on this occasion showed that the stoichiometry of these species do actually condition the bioavailability of the antibiotics in blood plasma during treatment, the fraction of free base being quite negligible with regard to the metal-bound one. The present paper completes this study with the investigation of the mixed-metal complexes given rise to by calcium and magnesium with the same antibiotics. Such ternary species have been proved to exist for tetracycline, oxytetracycline, and minocycline. Their involvement in the plasma distribution of these drugs is discussed, in relation with the potential abilities of the four tetracyclines to diffuse from plasma into tissue membranes.
本系列前文研究了钙和镁分别与四环素、土霉素、强力霉素和米诺环素形成的络合物的平衡。此次进行的计算机模拟表明，这些物质的化学计量确实会影响治疗期间抗生素在血浆中的生物利用度，与金属结合的游离碱部分相比，游离碱部分可忽略不计。本文通过研究钙和镁与相同抗生素形成的混合金属络合物，完善了这项研究。已证明四环素、土霉素和米诺环素存在此类三元物质。结合四种四环素从血浆扩散到组织膜的潜在能力，讨论了它们在这些药物血浆分布中的作用。
