Dixon A J, Davies J, Dormandy T L, Hamilton E B, Holt P J, Mason R M, Thompson M, Weber J C, Zutshi D W
Ann Rheum Dis. 1975 Oct;34(5):416-21. doi: 10.1136/ard.34.5.416.
Doses of 600 mg and 1200 mg of D(-)penicillamine daily were superior to a standard regimen of therapy in rheumatoid arthritis. The higher dose did not produce significantly greater therapeutic benefit in the group of patients so treated, although individual patients sometimes improved more. The frequency of rashes, blood dyscrasias, and withdrawals from the trial increased withe dosage. It is concluded that D(-)penicillamine is a useful treatment that the daily dose should be as low as possible, and that it should be increased at infrequent intervals only, with due regard to the likelihood of further improvement in relation to an increased risk of adverse reactions.
每日服用600毫克和1200毫克的D（-）青霉胺治疗类风湿性关节炎，疗效优于标准治疗方案。在接受该治疗的患者组中，较高剂量并未产生显著更大的治疗益处，尽管个别患者有时改善得更多。皮疹、血液系统异常的发生率以及试验中的退出率随剂量增加而上升。结论是，D（-）青霉胺是一种有效的治疗药物，日剂量应尽可能低，且仅应偶尔增加剂量，并充分考虑到不良反应风险增加的情况下进一步改善的可能性。
