Graf H, Stummvoll H K, Kovarik J, Meisinger V, Wolf A, Pinggera W F
Wien Klin Wochenschr. 1980;92(11):391-4.
Aluminium kinetics in patients with endstage renal failure and chronic intermittent haemodialysis have been studied. All patients revealed elevated predialytic serum aluminum levels. Because of a significant correlation between daily intake of aluminiumhydroxyd and serum aluminium levels it is concluded that the intestinal aluminium absorption plays an etiological role in the development of hyperaluminaemia. Plasma aluminium levels at the end of a regular dialysis procedure are significant lower compared to predialytic values. Similarly a significant decrease of aluminium concentration was observed in the plasma after passage through the dialyzer. This is due to the fact that the aluminium content of the dialysate used in our unit (0.1-0.3 mumol/l) is lower than the ultrafiltrable fraction of the plasma aluminium measured in vivo. Therefore a negative aluminium-balance during haemodialysis has to be assumed in our patients. Extreme aluminium-accummulation seems to be avoided and we therefore never experienced aluminium intoxication and dialysis dementia in our center. To assess a negative aluminium balance during haemodialysis, because of high protein binding of aluminium, a dialysate with an extreme low aluminium content has to be recommended.
对终末期肾衰竭及慢性间歇性血液透析患者的铝动力学进行了研究。所有患者透析前血清铝水平均升高。由于氢氧化铝的每日摄入量与血清铝水平之间存在显著相关性，因此得出结论，肠道铝吸收在高铝血症的发生中起病因学作用。常规透析程序结束时的血浆铝水平明显低于透析前值。同样，透析器通过后血浆中铝浓度显著降低。这是因为我们单位使用的透析液铝含量（0.1 - 0.3微摩尔/升）低于体内测得的血浆铝可超滤部分。因此，我们的患者在血液透析期间必须假定存在负铝平衡。似乎避免了极端的铝蓄积，因此我们中心从未经历过铝中毒和透析性痴呆。为了评估血液透析期间的负铝平衡，由于铝的高蛋白结合性，必须推荐使用铝含量极低的透析液。
