Gillam G L, McNicol K N, Williams H E
Arch Dis Child. 1970 Dec;45(244):789-99. doi: 10.1136/adc.45.244.789.
Studies were made on 56 10-11-year-old asthmatic children with onset of symptoms before 3 years of age, frequent and persistent attacks, and objective evidence of their disease with barrel chest deformity and/or reduction of the FEV /VC ratio to 50% or less, by clinical, physiological, and radiological techniques in an interval phase between their attacks. There was a significant correlation between barrel chest deformity and () elevation of lung volumes (FRC, RV, TLC, FRC/TLC, and RV/TLC), and () reduction of the FEV/VC ratio, indicating chronic hyperinflation and airways obstruction in the interval phase between attacks. Radiological evidence of hyperinflation also correlated significantly with barrel chest deformity, increased lung volumes, and airways obstruction. These parameters were found to be important criteria for assessing chronicity in asthma. The group showed evidence of growth retardation particularly for weight and to a lesser extent for height, these changes being most marked in subjects with barrel chest deformity. Corticosteroid therapy was not a significant factor in the growth retardation observed. There was a preponderance of males over females in the group (7:3).
对56名10 - 11岁的哮喘儿童进行了研究，这些儿童在3岁前出现症状，发作频繁且持续，通过临床、生理和放射学技术在发作间期对其疾病进行客观评估，发现有桶状胸畸形和/或FEV/VC比值降至50%或更低。桶状胸畸形与（1）肺容积（FRC、RV、TLC、FRC/TLC和RV/TLC）升高以及（2）FEV/VC比值降低之间存在显著相关性，表明在发作间期存在慢性肺过度充气和气道阻塞。肺过度充气的放射学证据也与桶状胸畸形、肺容积增加和气道阻塞显著相关。这些参数被认为是评估哮喘慢性化的重要标准。该组显示出生长发育迟缓的迹象，尤其是体重方面，身高方面程度较轻，这些变化在有桶状胸畸形的受试者中最为明显。皮质类固醇治疗并非观察到的生长发育迟缓的重要因素。该组中男性多于女性（7:3）。
