Balfour-Lynn L
Arch Dis Child. 1986 Nov;61(11):1049-55. doi: 10.1136/adc.61.11.1049.
Height and weight were measured every six months in a long term prospective study of 66 children with chronic perennial asthma for a mean 13.1 years. There was no evidence of growth retardation on entry into the study. Growth developed along normal lines in all 66 children until about 10 years, and in 35 of these children growth continued along normal lines throughout the whole period of follow up. Thirty children showed the physiological decelerating growth velocity pattern seen in children with delay in the onset of puberty, and one child had an early menarche. The tendency for delay in the onset of puberty was significant for both boys and girls and was noted to be independent of severity of asthma. Once puberty finally began in these children, complete catch up growth resulted in the attainment of the predicted adult height. Long term prophylactic inhalation of beclomethasone dipropionate in 26 children in a dosage up to 600 mcg/day before puberty and 400 mcg/day during puberty was shown not to affect growth. It is concluded that asthma had no direct influence on growth in height but was associated with delay in the onset of puberty. The pre-adolescent physiological deceleration of growth velocity that occurs in these children gives the impression of growth retardation.
在一项对66名慢性常年性哮喘儿童进行的为期平均13.1年的长期前瞻性研究中，每六个月测量一次身高和体重。进入研究时没有生长发育迟缓的证据。所有66名儿童在10岁左右之前生长发育正常，其中35名儿童在整个随访期间生长发育持续正常。30名儿童出现了青春期开始延迟的儿童所具有的生理性生长速度减慢模式，一名儿童初潮过早。青春期开始延迟的趋势在男孩和女孩中都很明显，并且被认为与哮喘的严重程度无关。一旦这些儿童最终进入青春期，完全的追赶生长导致达到预测的成人身高。对26名儿童在青春期前长期预防性吸入丙酸倍氯米松，剂量高达600微克/天，青春期期间为400微克/天，结果显示不影响生长。结论是，哮喘对身高增长没有直接影响，但与青春期开始延迟有关。这些儿童青春期前出现的生理性生长速度减慢给人以生长发育迟缓的印象。
