虫草素抑制5-碘-2'-脱氧尿苷诱导的鼠白血病病毒产生。
Cordycepin inhibits induction of murine leukovirus production by 5-iodo-2'-deoxyuridine.
作者信息
Wu A M, Ting R C, Paran M, Gallo R C
出版信息
Proc Natl Acad Sci U S A. 1972 Dec;69(12):3820-4. doi: 10.1073/pnas.69.12.3820.
Abstract
Cordycepin (3'-deoxyadenosine), an inhibitor of poly(A) synthesis during the processing of nuclear heterogenous RNA, blocks the production of RNA viruses induced by 5-iodo-2'-deoxyuridine in BALB/3T3 and BALB/K-3T3 cells. This inhibitory activity is not a result of either nonspecific cell killing or general cytotoxicity by cordycepin; rather, it appears to be specific, because cordycepin acts only at a critical time to inhibit virus production. These findings, together with the finding of poly(A) sequences in viral RNAs, suggest that RNA tumor viruses replicate via a transcription of proviral DNA.
摘要
虫草素（3'-脱氧腺苷）是核不均一RNA加工过程中聚腺苷酸合成的抑制剂，可阻断5-碘-2'-脱氧尿苷在BALB/3T3和BALB/K-3T3细胞中诱导产生的RNA病毒。这种抑制活性并非虫草素非特异性细胞杀伤或一般细胞毒性的结果；相反，它似乎具有特异性，因为虫草素仅在关键时间发挥作用以抑制病毒产生。这些发现，连同在病毒RNA中发现聚腺苷酸序列，表明RNA肿瘤病毒通过前病毒DNA的转录进行复制。
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