Burlakova E B, Molochkina E M, Pal'mina N P, Slepukhina L V
Vopr Med Khim. 1976 Jul-Aug;22(4):541-6.
Antioxidative activity (AOA) of lipids in mice liver was decreased in the old animals. The rate of the AOA decrease varied in different strains of mice. Alteration in the AOA is a phenomenon typical, but unspecific, for the senescence process. Senescence belongs to the pathological states, which occur at the decreased level of the AOA. Similar alterations in AOA were noted in radiation disease, stress state, hyperoxia, intoxications. Development of these pathological states could be inhibited or prevented by means of substances, increasing the antioxidative activity. At the same time the substances, known as inhibitors of senescence, were shown to increase the AOA in vivo. The effect of substances on the antioxidative activity of lipids is considered as a useful test for selection of agents, which appear promising as drugs for prolongation of survival periods.
老年小鼠肝脏中脂质的抗氧化活性（AOA）降低。AOA降低的速率在不同品系的小鼠中有所不同。AOA的改变是衰老过程中的一种典型但非特异性的现象。衰老属于病理状态，发生在AOA水平降低时。在放射病、应激状态、高氧、中毒等情况中也观察到了类似的AOA改变。通过增加抗氧化活性的物质可以抑制或预防这些病理状态的发展。同时，已知的衰老抑制剂在体内可增加AOA。物质对脂质抗氧化活性的影响被认为是筛选有望作为延长生存期药物的有用测试。
