Cope F W
Biophys J. 1970 Sep;10(9):843-58. doi: 10.1016/S0006-3495(70)86339-1.
Na(+) in muscle, brain, and kidney is shown by spin-echo nuclear magnetic resonance (NMR) to consist of two fractions with different NMR parameters. The slow fraction of Na(+) in these tissues has NMR relaxation times T(1) and T(2) of 10-15 x 10(-3) sec, which is approximately 4-5 times shorter than for Na(+) in aqueous NaCl solution. The slow fraction may represent Na(+) dissolved in structured tissue water. The fast fraction of tissue Na(+), which is shown to represent approximately 65% of the total tissue Na(+) concentration, has T(2) less than 1 x 10(-3) sec, which resembles the values of T(2) observed for Na(+) complexed by synthetic ion-exchange resins. One is drawn to the conclusion that approximately 65% of total Na(+) in muscle, brain, and kidney is complexed by tissue macromolecules.
通过自旋回波核磁共振（NMR）显示，肌肉、大脑和肾脏中的Na⁺由具有不同NMR参数的两个部分组成。这些组织中Na⁺的慢部分具有10 - 15×10⁻³秒的NMR弛豫时间T₁和T₂，这比NaCl水溶液中Na⁺的弛豫时间短约4 - 5倍。慢部分可能代表溶解在结构化组织水中的Na⁺。组织Na⁺的快部分显示约占总组织Na⁺浓度的65%，其T₂小于1×10⁻³秒，这类似于合成离子交换树脂络合的Na⁺所观察到的T₂值。由此得出结论，肌肉、大脑和肾脏中约65%的总Na⁺与组织大分子络合。
