Casu M, Corongiu F P, Dessì M A, Frau M, Lai A
Biochem Biophys Res Commun. 1986 Feb 13;134(3):1079-85. doi: 10.1016/0006-291x(86)90361-x.
Intracellular Na-23 NMR signals were analyzed to investigate the T1 nuclear magnetic relaxation times of sodium ions in rat tissues under physiological conditions in presence of the shift reagent Dy(PPPi)2(7-). The T1 values so measured showed a high degree of reproducibility (10%). The order of T1 values found for the investigated rat tissues was the following: liver, spleen less than kidney less than muscle, brain less than blood. Furthermore, livers of rats treated with the known hepatotoxic agent CCl4 were studied. This tissue showed a significative increase of T1 with respect to those of normal rats. The T1 lengthenings were discussed in terms of various cellular injuries induced in the liver by CCl4 intoxication and our results showed that T1 lengthening did not depend on liver necrosis.
分析细胞内钠-23核磁共振信号，以研究在位移试剂Dy(PPPi)2(7-)存在的生理条件下大鼠组织中钠离子的T1核磁弛豫时间。如此测得的T1值显示出高度的可重复性（10%）。在所研究的大鼠组织中发现的T1值顺序如下：肝脏、脾脏小于肾脏小于肌肉、大脑小于血液。此外，还研究了用已知肝毒性剂四氯化碳处理的大鼠的肝脏。该组织相对于正常大鼠的组织显示出T1的显著增加。根据四氯化碳中毒在肝脏中引起的各种细胞损伤讨论了T1延长，我们的结果表明T1延长不依赖于肝坏死。
