体内血小板对多巴胺的摄取。
Uptake of dopamine by platelets in vivo.
作者信息
Boullin D J, McMahon E M, O'Brien R A
出版信息
Br J Pharmacol. 1970 Nov;40(3):522-3. doi: 10.1111/j.1476-5381.1970.tb10634.x.
Abstract
Circulating platelets of cats infused with (14)C-dopamine take up the amine against a concentration gradient, with maximal concentration occurring 10 min after infusion. 58%, of the platelet-bound radioactive dopamine was localized in a subcellular fraction rich in 5-hydroxytryptamine (5-HT) storage organelles. The results support earlier work with human platelets showing in vitro dopamine uptake by normal platelets, and in vivo accumulation in parkinsonian patients treated with L-dopa.
摘要
给猫输注（14）C-多巴胺后，循环中的血小板会逆浓度梯度摄取胺，输注后10分钟达到最大浓度。与血小板结合的放射性多巴胺中有58%定位于富含5-羟色胺（5-HT）储存细胞器的亚细胞部分。这些结果支持了早期对人类血小板的研究，该研究表明正常血小板在体外可摄取多巴胺，且接受左旋多巴治疗的帕金森病患者体内会有蓄积。
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本文引用的文献
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2
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