Nikolova Z, Zakstel'skaia L Ia, Kotseva R, Molibog E V
Vopr Virusol. 1975 Sep-Oct(5):553-6.
Antineuraminidase and antihemagglutinating antibody studies were carried out in parallel in sera from subjects born in Bulgaria in 1968-1972, 1956-1960, 1946-1950, 1925-1935 and 1917-1920. It was found that the amount of both antineuraminidase and antihemagglutinating antibody in sera from normal subjects could vary depending upon the year of birth and the strain used for the test. The antibody spectrum was most narrow in children under 4 and wider in subjects born before 1925. Serograms of the age distribution of antineuraminidase antibody were different in 4 out of 5 strains used which confirmed the hypothesis of Francis and Davenport of the more solid immunological response to the first exposure to virus. Parallel examinations of the antibody spectrum in human sera confirmed differences in the antigenic specificity of the "active center" of neuraminidases of A/Hong Kong/1/68 (H3N2) and A/Singapore/1/57 (H2N2) viruses and for the first time provided evidence attesting to the existence of similar strain differences in neuraminidases belonging to the N1 group. Examinations for antineuraminidase antibody in addition to antihemagglutinins increase the effectiveness of evaluation of the immunological structure of the population.
对1968 - 1972年、1956 - 1960年、1946 - 1950年、1925 - 1935年和1917 - 1920年出生于保加利亚的受试者血清进行了抗神经氨酸酶和抗血凝抗体研究。结果发现，正常受试者血清中抗神经氨酸酶和抗血凝抗体的量可能因出生年份和用于检测的毒株而异。4岁以下儿童的抗体谱最窄，1925年以前出生的受试者的抗体谱较宽。在所使用的5种毒株中，有4种毒株的抗神经氨酸酶抗体年龄分布血清图不同，这证实了弗朗西斯和达文波特关于首次接触病毒时免疫反应更强的假说。对人血清中抗体谱的平行检测证实了A/香港/1/68（H3N2）和A/新加坡/1/57（H2N2）病毒神经氨酸酶“活性中心”抗原特异性的差异，并首次提供了证据证明属于N1组的神经氨酸酶存在类似的毒株差异。除了抗血凝素外，检测抗神经氨酸酶抗体可提高对人群免疫结构评估的有效性。
