• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

幼年雪貂、兔子、豚鼠、猫和鸡摄取聚乙烯吡咯烷酮后小肠的结构变化。

Structural changes in the small intestine associated with the uptake of polyvinyl pyrrolidone by the young ferret, rabbit, guinea-pig, cat and chicken.

作者信息

Clarke R M, Hardy R N

出版信息

J Physiol. 1970 Aug;209(3):669-87. doi: 10.1113/jphysiol.1970.sp009185.

DOI:10.1113/jphysiol.1970.sp009185
PMID:5499802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1395547/
Abstract
  1. The entry of [(125)I]polyvinyl pyrrolidone (PVP) of mean mol. wt. 160,000 (K. 60) into the epithelial cells of the small intestine has been measured in new-born animals of five species.2. The distribution along the intestine of cells capable of taking up [(125)I]PVP and the decrease and eventual cessation of uptake (closure) with increasing age have been investigated, and have been related to changes in the histological appearance of the small intestine.3. The small intestine of the ferret took up PVP readily until 33-34 days after birth. From 34 to 37 days of age PVP uptake declined sharply and disappeared completely by 40-45 days.4. In the ferret, unlike other species studied, some PVP was taken up by the duodenum. This continued for the first 4 weeks after birth. Thereafter PVP uptake gradually became confined to the terminal ileum.5. In the guinea-pig, PVP uptake was limited to the first 48 hr after birth. During this period the site of uptake was progressively restricted to the terminal ileum.6. In the rabbit, PVP could be taken up in the distal two-thirds of the small intestine for at least 20 days after birth. A decline in uptake occurred between 20 and 22 days after birth in most animals.7. Wide individual variations were seen in the kitten, but PVP uptake was seen in some animals up to 14 days after birth.8. Newly hatched chicks and chicks tested 48 hr after hatching did not take up PVP.9. Histological examination of the small intestine with the light microscope demonstrated that in all species PVP uptake was associated with the presence of vacuoles in the epithelial cells of the villus.10. In the young guinea-pig, large PAS-positive granules were seen in the macrophages of the lamina propria. These appeared to migrate through the epithelium into the intestinal lumen. The significance of this finding and its relation to macromolecular uptake remain unclear.
摘要

  1. 已在五种新生动物中测量了平均分子量为160,000（K.60）的[(125)I]聚乙烯吡咯烷酮（PVP）进入小肠上皮细胞的情况。

  2. 研究了能够摄取[(125)I]PVP的细胞在肠道中的分布情况，以及随着年龄增长摄取量的减少和最终停止（封闭）的情况，并将其与小肠组织学外观的变化相关联。

  3. 雪貂的小肠在出生后33 - 34天之前很容易摄取PVP。从34到37日龄，PVP摄取量急剧下降，到40 - 45天时完全消失。

  4. 与其他研究的物种不同，雪貂的十二指肠会摄取一些PVP。这种情况在出生后的前4周持续存在。此后，PVP摄取逐渐局限于回肠末端。

  5. 在豚鼠中，PVP摄取仅限于出生后的前48小时。在此期间，摄取部位逐渐局限于回肠末端。

  6. 在兔子中，出生后至少20天内，小肠远端三分之二的部位都能摄取PVP。大多数动物在出生后20至22天之间摄取量出现下降。

  7. 小猫个体差异很大，但在一些动物中，出生后14天仍能观察到PVP摄取。

  8. 刚孵化的雏鸡和孵化后48小时检测的雏鸡不摄取PVP。

  9. 用光学显微镜对小肠进行组织学检查表明，在所有物种中，PVP摄取都与绒毛上皮细胞中液泡的存在有关。

  10. 在幼豚鼠中，固有层巨噬细胞中可见大量PAS阳性颗粒。这些颗粒似乎穿过上皮细胞进入肠腔。这一发现的意义及其与大分子摄取的关系尚不清楚。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/594d/1395547/397ace0c9331/jphysiol01050-0177-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/594d/1395547/63c79bd3bf75/jphysiol01050-0175-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/594d/1395547/7f8a02488679/jphysiol01050-0176-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/594d/1395547/397ace0c9331/jphysiol01050-0177-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/594d/1395547/63c79bd3bf75/jphysiol01050-0175-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/594d/1395547/7f8a02488679/jphysiol01050-0176-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/594d/1395547/397ace0c9331/jphysiol01050-0177-a.jpg

相似文献

1
Structural changes in the small intestine associated with the uptake of polyvinyl pyrrolidone by the young ferret, rabbit, guinea-pig, cat and chicken.幼年雪貂、兔子、豚鼠、猫和鸡摄取聚乙烯吡咯烷酮后小肠的结构变化。
J Physiol. 1970 Aug;209(3):669-87. doi: 10.1113/jphysiol.1970.sp009185.
2
An analysis of the mechanism of cessation of uptake of macromolecular substances by the intestine of the young rat ('closure').幼鼠肠道对大分子物质摄取停止机制（“封闭”）的分析
J Physiol. 1969 Sep;204(1):127-34. doi: 10.1113/jphysiol.1969.sp008903.
3
The use of [125-I] polyvinyl pyrrolidone K. 60 in the quantitative assessment of the uptake of macromolecular substances by the intestine of the young rat.[125-I]聚乙烯吡咯烷酮K.60在幼鼠肠道对大分子物质摄取的定量评估中的应用
J Physiol. 1969 Sep;204(1):113-25. doi: 10.1113/jphysiol.1969.sp008902.
4
The influence of exogenous steroids on macromolecule uptake by the small intestine of the new-born rat.外源性类固醇对新生大鼠小肠大分子摄取的影响。
J Physiol. 1973 Mar;229(3):681-95. doi: 10.1113/jphysiol.1973.sp010160.
5
The absorption of polyvinyl pyrrolidone by the new-born pig intestine.新生猪肠道对聚乙烯吡咯烷酮的吸收
J Physiol. 1969 Oct;204(3):633-51. doi: 10.1113/jphysiol.1969.sp008936.
6
Factors influencing the uptake of [ 125 I]polyvinyl pyrrolidone by the intestine of the young rat.影响幼鼠肠道对[125I]聚乙烯吡咯烷酮摄取的因素。
J Physiol. 1971 Feb;212(3):801-17. doi: 10.1113/jphysiol.1971.sp009357.
7
The influence of specific chemical factors in the solvent on the absorption of macromolecular substances from the small intestine of the new-born calf.溶剂中特定化学因素对新生小牛小肠中大分子物质吸收的影响。
J Physiol. 1969 Oct;204(3):607-32. doi: 10.1113/jphysiol.1969.sp008935.
8
The effect of adrenalectomy or pharmacological inhibition of adrenocortical function on macromolecule uptake by the new-born rat intestine.肾上腺切除术或肾上腺皮质功能的药理学抑制对新生大鼠肠道大分子摄取的影响。
J Physiol. 1973 Mar;229(3):697-707. doi: 10.1113/jphysiol.1973.sp010161.
9
Lamina propria macrophages of intestine of the guinea pig. Possible role in phagocytosis of migrating cells.豚鼠肠道固有层巨噬细胞。在迁移细胞吞噬作用中的可能作用。
Gastroenterology. 1977 Dec;73(6):1340-4.
10
Growth and morphological changes in the small and the large intestine in piglets during the first three days after birth.仔猪出生后前三天小肠和大肠的生长及形态变化
J Dev Physiol. 1992 Oct;18(4):161-72.

引用本文的文献

1
Building better barriers: how nutrition and undernutrition impact pediatric intestinal health.建立更好的屏障：营养和营养不足如何影响儿科肠道健康。
Front Immunol. 2023 Jul 21;14:1192936. doi: 10.3389/fimmu.2023.1192936. eCollection 2023.
2
Autoradiographic analysis of alanine uptake by newborn pig intestine.新生猪肠道对丙氨酸摄取的放射自显影分析。
Experientia. 1981;37(8):868-70. doi: 10.1007/BF01985687.
3
Maturation in the ferret ileal epithelium and the effect of cortisone acetate.雪貂回肠上皮的成熟及醋酸可的松的作用

本文引用的文献

1
Acceleration of the absorption of unchanged globulin in the new-born calf by factors in colostrum.初乳中的因子对新生小牛未改变的球蛋白吸收的促进作用。
J Physiol. 1962 Feb;160(2):234-57. doi: 10.1113/jphysiol.1962.sp006844.
2
The transfer of serum proteins from mother to young in the guinea pig. III. Postnatal studies.豚鼠中血清蛋白从母体到幼体的转移。III. 产后研究。
Am J Anat. 1961 Sep;109:175-81. doi: 10.1002/aja.1001090207.
3
TRANSFER OF GAMMA GLOBULIN FROM MOTHER TO OFFSPRING IN MINK.
J Anat. 1983 Mar;136(Pt 2):401-5.
4
Maturation of the ileal epithelium in the young rat.幼鼠回肠上皮的成熟
J Anat. 1983 Sep;137 (Pt 2)(Pt 2):357-69.
5
Factors influencing the uptake of [ 125 I]polyvinyl pyrrolidone by the intestine of the young rat.影响幼鼠肠道对[125I]聚乙烯吡咯烷酮摄取的因素。
J Physiol. 1971 Feb;212(3):801-17. doi: 10.1113/jphysiol.1971.sp009357.
6
Endocytosis and immunoglobulin transport across the small intestine of the new-born pig.新生仔猪小肠的内吞作用及免疫球蛋白转运
J Physiol. 1977 Sep;270(2):473-88. doi: 10.1113/jphysiol.1977.sp011963.
7
The postnatal development of the alimentary canal in the opossum. III. Small intestine and colon.负鼠消化道的产后发育。III. 小肠和结肠。
J Anat. 1977 Feb;123(Pt 1):21-45.
Proc Soc Exp Biol Med. 1965 May;119:131-3. doi: 10.3181/00379727-119-30117.
4
THE TRANSMISSION OF ANTIBODIES AND NORMAL GAMMA-GLOBULINS ACROSS THE YOUNG MOUSE GUT.抗体和正常丙种球蛋白在幼鼠肠道中的传递
Proc R Soc Lond B Biol Sci. 1964 May 19;160:276-92. doi: 10.1098/rspb.1964.0040.
5
THE SELECTION OF ANTIBODIES BY THE GUT OF THE YOUNG HEDGEHOG.
Proc R Soc Lond B Biol Sci. 1963 Sep 17;158:253-60. doi: 10.1098/rspb.1963.0046.
6
[Rearing of premature infants with colostrum. Maturation of the immuno-globulins in newborn and premature infants].[用初乳喂养早产儿。新生儿和早产儿免疫球蛋白的成熟情况]
Arch Fr Pediatr. 1962 May;19:663-76.
7
The transfer of antibodies from the mother cat to her newborn kittens.抗体从母猫向其新生小猫的转移。
Cornell Vet. 1961 Oct;51:535-9.
8
[Electrophoretic study of the serum and plasma of the cat].[猫血清和血浆的电泳研究]
C R Seances Soc Biol Fil. 1961;155:737-42.
9
The lack of absorption of ingested bovine antibody in humans.人体对摄入的牛抗体缺乏吸收。
J Immunol. 1959 Oct;83:437-41.
10
Further studies on proteinuria in the new-born calf.新生犊牛蛋白尿的进一步研究。
J Physiol. 1961 Apr;156(1):136-49. doi: 10.1113/jphysiol.1961.sp006664.