Spencer H, Kramer L, Osis D, Norris C
Isr J Med Sci. 1976 Jul;12(7):638-51.
Studies carried out in this Research Unit and by others have shown that patients with osteoporosis absorb less calcium from a high calcium intake than do patients without osteoporosis. To determine whether various treatment modalities would increase the intestinal absorption of calcium, the effects of conventional and new methods were investigated. Tracer doses of 47Ca were given orally to determine the absorption of calcium. Calcium balances were also determined. Estrogen decreased urinary calcium and testosterone increased the nitrogen balance. Vitamin D and strontium increased the urinary calcium but did not increase calcium absorption. Of the newer compounds, fluoride did not affect calcium absorption but decreased urinary calcium. Phosphate had a similar effect. Infusions containing up to 15 mg calcium/kg, given for 6 or 10 days, increased the retention of calcium but did not increase its absorption.
在本研究单位及其他机构开展的研究表明，与非骨质疏松症患者相比，骨质疏松症患者从高钙摄入量中吸收的钙更少。为了确定各种治疗方式是否会增加肠道对钙的吸收，对传统方法和新方法的效果进行了研究。口服示踪剂量的47Ca以测定钙的吸收情况。还测定了钙平衡。雌激素减少尿钙，睾酮增加氮平衡。维生素D和锶增加尿钙，但未增加钙吸收。在新型化合物中，氟化物不影响钙吸收，但减少尿钙。磷酸盐有类似作用。给予含高达15mg钙/千克的输注液，持续6天或10天，增加了钙的潴留，但未增加其吸收。
