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一株源自膀胱移行细胞肿瘤的人组织培养细胞系：生长、染色体模式及超微结构

A human tissue culture cell line from a transitional cell tumour of the urinary bladder: growth, chromosone pattern and ultrastructure.

作者信息

Rigby C C, Franks L M

出版信息

Br J Cancer. 1970 Dec;24(4):746-54. doi: 10.1038/bjc.1970.89.

DOI:10.1038/bjc.1970.89
PMID:5503601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2008730/
Abstract

Cell cultures were made from 18 human bladder tumours. Three cell lines were maintained for seven transfer generations, but all had a "fibroblastic" morphology and a normal diploid karyotype. A fourth line has been maintained for over 80 transfer generations. This was derived from a well differentiated papillary tumour of bladder. Morphologically the light and electron microscopic structure of the cells resembled that of bladder tumours. The cells formed tumour nodules, with a similar structure, when transplanted into hamster cheek pouches. There is a stem line chromosome number of 48. Karyotypes of 60% of the stem line cells had one extra chromosome in Group C and one in Group D.

摘要

从18个人类膀胱肿瘤中进行细胞培养。三个细胞系传代培养了七代，但所有细胞系都具有“成纤维细胞样”形态和正常的二倍体核型。第四个细胞系已传代培养超过80代。它源自膀胱的一个高分化乳头状肿瘤。从形态学上看，这些细胞的光镜和电镜结构与膀胱肿瘤相似。当将这些细胞移植到仓鼠颊囊中时，它们形成了结构相似的肿瘤结节。主干染色体数为48条。60%的主干细胞系核型在C组有一条额外染色体，在D组有一条额外染色体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0934/2008730/0ee17e9ca85c/brjcancer00469-0151-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0934/2008730/a7e9468cd71c/brjcancer00469-0152-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0934/2008730/94328de4b1e4/brjcancer00469-0153-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0934/2008730/82d2afbb0323/brjcancer00469-0154-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0934/2008730/10014373dc94/brjcancer00469-0155-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0934/2008730/a11507f3a346/brjcancer00469-0149-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0934/2008730/38926c0f98f7/brjcancer00469-0156-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0934/2008730/7d22be1a172e/brjcancer00469-0150-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0934/2008730/0ee17e9ca85c/brjcancer00469-0151-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0934/2008730/a7e9468cd71c/brjcancer00469-0152-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0934/2008730/94328de4b1e4/brjcancer00469-0153-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0934/2008730/82d2afbb0323/brjcancer00469-0154-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0934/2008730/10014373dc94/brjcancer00469-0155-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0934/2008730/a11507f3a346/brjcancer00469-0149-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0934/2008730/38926c0f98f7/brjcancer00469-0156-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0934/2008730/7d22be1a172e/brjcancer00469-0150-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0934/2008730/0ee17e9ca85c/brjcancer00469-0151-a.jpg

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