Buchanan N, Joubert P, Eyberg C, de Villiers F
S Afr Med J. 1979 Oct 13;56(16):638-40.
Serum and salivary digoxin concentrations were measured in 53 children and correlated with ECG variables and serum potassium, calcium and magnesium concentrations. In 73% of patients cardiac failure was controlled, while only 7,5% of patients had serum digoxin concentrations within the 'therapeutic range'. It is proposed that the adult therapeutic range of 1-2 ng/ml is not applicable to children, who can be controlled at lower concentrations and/or that a significant proportion of the children studied no longer required maintenance digoxin therapy.
对53名儿童测定了血清和唾液地高辛浓度，并将其与心电图变量以及血清钾、钙和镁浓度进行关联。73%的患者心力衰竭得到控制，而只有7.5%的患者血清地高辛浓度在“治疗范围”内。有人提出，1-2 ng/ml的成人治疗范围不适用于儿童，儿童在较低浓度下即可得到控制，和/或所研究的相当一部分儿童不再需要维持地高辛治疗。
