Botha P, Berman P A, Elisha G, Callanan J J
S Afr Med J. 1979 Aug 11;56(6):211-3.
More than 2 years of experience in assaying aminoglycoside antibiotic levels have proved that the appropriate acetyltransferase employed in conjunction with 14C-acetyl co-enzyme A provides rapid, reproducible results (CV = 4+). These results are available before the next administration is due, enabling the clinician to adjust the dose. This is especially indicated if there is impairment of renal function.
超过2年的氨基糖苷类抗生素水平检测经验证明,与14C - 乙酰辅酶A联合使用的合适的乙酰转移酶能提供快速、可重复的结果(变异系数 = 4%+)。在下一次给药前就能得到这些结果,使临床医生能够调整剂量。如果存在肾功能损害,这一点尤为重要。