Cheuk S F, Hahn H H, Moore D M, Krause D N, Tomasulo P A, Wood W B
J Exp Med. 1970 Jul 1;132(1):127-33. doi: 10.1084/jem.132.1.127.
Suppression of the pyrogen-producing capacity of exudate granulocytes results from incubation of the cells in plasma, serum, or Ringer's solution. When transferred in this state and incubated in isotonic NaCl, the cells release much less pyrogen than untreated exudate cells. The suppressive effect is reversible and appears to involve the cellular uptake of calcium ions. In contrast, regeneration of pyrogen-producing capacity in depleted exudate cells occurs only when the cells are incubated in serum. The process resembles activation and requires the cellular synthesis of protein.
渗出性粒细胞产生热原能力的抑制是由于细胞在血浆、血清或林格氏溶液中孵育所致。当处于这种状态下转移并在等渗氯化钠中孵育时，这些细胞释放的热原比未处理的渗出细胞少得多。这种抑制作用是可逆的，似乎涉及细胞对钙离子的摄取。相比之下，耗尽的渗出细胞中产生热原能力的恢复仅在细胞在血清中孵育时才会发生。这个过程类似于激活，需要细胞合成蛋白质。
