发热的发病机制研究。18. 白细胞产热原的激活。
Studies on the pathogenesis of fever. 18. Activation of leukocytes for pyrogen production.
作者信息
Moore D M, Cheuk S F, Morton J D, Berlin R D, Wood W B
出版信息
J Exp Med. 1970 Jan 1;131(1):179-88. doi: 10.1084/jem.131.1.179.
Abstract
Blood leukocytes, in contrast to exudate leukocytes, release little or no pyrogen when incubated in 0.15 M NaCl unless previously activated by exposure to endotoxin or to a protein activator that is present in acute exudate fluid. The activation process, which also occurs during phagocytosis, involves the synthesis of cellular protein, presumably related to the pyrogen molecule. Evidence is presented that generation of pyrogen in sterile inflammatory lesions depends on both the activator and the anaerobic conditions in the exudate fluid.
摘要
与渗出液中的白细胞不同，血液中的白细胞在0.15M氯化钠中孵育时，除非先前通过接触内毒素或急性渗出液中存在的蛋白质激活剂而被激活，否则很少释放或不释放热原。激活过程也发生在吞噬作用期间，涉及细胞蛋白质的合成，推测与热原分子有关。有证据表明，无菌性炎症病变中热原的产生取决于激活剂和渗出液中的厌氧条件。
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