一种抗有丝分裂药物对感染的细胞介导免疫的抑制作用。迁移性巨噬细胞表达免疫的进一步证据。
Suppression of cell-mediated immunity to infection by an antimitotic drug. Further evidence that migrant macrophages express immunity.
作者信息
North R J
出版信息
J Exp Med. 1970 Sep 1;132(3):535-45. doi: 10.1084/jem.132.3.535.
Abstract
The development of acquired cell-mediated immunity to infection with Listeria monocytogenes can be blocked by a 15 hr pulse of the antimitotic drug, vinblastine (Vb). The drug has no effect on the host-parasite relationship after 72 hr of infection when a high level of immunity is being expressed, i.e., when infective foci are populated by activated macrophages. Infective foci in mice treated early during infection with Vb do not acquire migrant macrophages, but they become acellular after 48 hr of infection. The results indicate that Vb destroys the dividing precursors of migrant macrophages. The possibility that Vb prevents the activation of these cells by destroying dividing lymphoid cells engaged in the specific immunological phase of the host response is also considered.
摘要
抗有丝分裂药物长春碱（Vb）15小时的脉冲处理可阻断机体对单核细胞增生李斯特菌感染获得性细胞介导免疫的发展。在感染72小时后，当机体表现出高水平免疫时，即感染灶中有活化巨噬细胞存在时，该药物对宿主-寄生虫关系没有影响。在感染早期用Vb处理的小鼠，其感染灶不会募集游走巨噬细胞，但在感染48小时后会变成无细胞状态。结果表明，Vb破坏了游走巨噬细胞的分裂前体细胞。还考虑了Vb通过破坏参与宿主反应特异性免疫阶段的分裂淋巴细胞来阻止这些细胞活化的可能性。
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The action of the vincaleukolastine on mitosis in vitro.长春新碱在体外对有丝分裂的作用。
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The relative importance of blood monocytes and fixed macrophages to the expression of cell-mediated immunity to infection.血液单核细胞和固定巨噬细胞在细胞介导的抗感染免疫表达中的相对重要性。
J Exp Med. 1970 Sep 1;132(3):521-34. doi: 10.1084/jem.132.3.521.
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