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正常淋巴细胞与淋巴样细胞系细胞的相互作用。II. 与细胞系来源和淋巴细胞供体相关的变异

The interaction of normal lymphocytes and cells from lymphoid cell lines. II. Variations relating to cell line source and lymphocyte donor.

作者信息

Knight S, Hardy D A, Ling N R

出版信息

Immunology. 1970 Aug;19(2):343-51.

PMID:5528388
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1455758/
Abstract

Irradiated LCL cells from several sources activated the blood lymphocytes of a panel of donors. Individual differences were present but were small. Stimulated blood lymphocytes were more potent activators (after X-irradiation) than small lymphocytes in a one-way mixed lymphocyte reaction, indicating that the state of metabolic activity of the `stimulating' lymphocyte affects the level of activation achieved. However, LCL cells incubated for several days after irradiation had not lost stimulatory capacity. Lymphocytes of pigs, rabbits, rats and mice were much less responsive than human lymphocytes. The response of animal lymphocytes generally varied with the species of origin of the serum used in the cultures.

摘要

来自多个来源的经辐照的LCL细胞激活了一组供体的血液淋巴细胞。存在个体差异，但差异较小。在单向混合淋巴细胞反应中，受刺激的血液淋巴细胞（经X射线照射后）比小淋巴细胞是更强效的激活剂，这表明“刺激”淋巴细胞的代谢活性状态会影响激活的程度。然而，辐照后培养数天的LCL细胞并未丧失刺激能力。猪、兔、大鼠和小鼠的淋巴细胞反应性远低于人类淋巴细胞。动物淋巴细胞的反应通常随培养中所用血清的来源物种而变化。

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引用本文的文献

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The interaction of normal lymphocytes and cells from lymphoid cell lines. IV. HL-A typing of the cell line cells.正常淋巴细胞与淋巴样细胞系细胞的相互作用。IV. 细胞系细胞的HL - A分型
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The interaction of normal lymphocytes nd cells from lymphoid cell lines. 3. Studies on activation in an autochthonous system.正常淋巴细胞与来自淋巴样细胞系的细胞之间的相互作用。3. 对自身系统中激活作用的研究。
Immunology. 1973 Jan;24(1):177-89.

本文引用的文献

1
Quantitative studies on the mixed lymphocyte interaction in rats. II. Relationship of the proliferative response to the immunologic status of the donors.大鼠混合淋巴细胞相互作用的定量研究。II. 增殖反应与供体免疫状态的关系。
J Exp Med. 1967 Oct 1;126(4):655-65. doi: 10.1084/jem.126.4.655.
2
Immunoglobulin synthesis in vitro by established human cell lines.
Science. 1966 May 27;152(3726):1259-61. doi: 10.1126/science.152.3726.1259.
3
The immunogenic capacity of antigen taken up by peritoneal exudate cells.腹膜渗出细胞摄取的抗原的免疫原性能力。
Immunology. 1969 Jan;16(1):1-14.
4
Chromosome markers in cultured cells from Burkitt's lymphoma.
Eur J Cancer (1965). 1968 Dec;4(6):637-46. doi: 10.1016/0014-2964(68)90048-0.
5
Antigens on human fibroblasts demonstrated with HL-A antisera and anti-human lymphocytic sera.用HL-A抗血清和抗人淋巴细胞血清显示的人成纤维细胞上的抗原。
Vox Sang. 1968;15(1):44-53. doi: 10.1111/j.1423-0410.1968.tb04446.x.
6
Aggregation and transformation of rat lymphocytes on rat embryo monolayers.大鼠淋巴细胞在大鼠胚胎单层细胞上的聚集与转化
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7
Lymphocyte transformation in vitro. 3. Mechanism of stimulation in the mixed lymphocyte culture.体外淋巴细胞转化。3. 混合淋巴细胞培养中的刺激机制。
Clin Exp Immunol. 1970 Aug;7(2):229-39.
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Cell-mediated immunity--general perspectives.
Br Med Bull. 1967 Jan;23(1):93-7. doi: 10.1093/oxfordjournals.bmb.a070525.
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Immunofluorescent studies of immunoglobulins in human lymphoid cells in continuous culture.
J Immunol. 1968 Aug;101(2):366-73.
10
Cloning of immunoglobulin-producing human leukemic and lymphoma cells in long-term cultures.长期培养中产生免疫球蛋白的人白血病和淋巴瘤细胞的克隆
Proc Soc Exp Biol Med. 1967 Jan;124(1):107-11. doi: 10.3181/00379727-124-31677.

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