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Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes.植物血凝素：正常人白细胞培养中细胞有丝分裂的启动剂。
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A human skin culture technique used for cytological examinations.一种用于细胞学检查的人体皮肤培养技术。
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LYMPHOCYTE TRANSFORMATION IN CULTURES OF MIXED LEUCOCYTES: A POSSIBLE TEST OF HISTOCOMPATIBILITY.混合白细胞培养中的淋巴细胞转化：一种可能的组织相容性检测方法。
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HOMOGRAFT SENSITIVITY REACTIONS IN IRRADIATED HAMSTERS.经辐照仓鼠的同种移植敏感性反应
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THE ACTION OF STREPTOLYSIN S ON PERIPHERAL LYMPHOCYTES OF NORMAL SUBJECTS AND PATIENTS WITH ACUTE RHEUMATIC FEVER.链球菌溶血素S对正常人和急性风湿热患者外周淋巴细胞的作用
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THE DEVELOPMENT OF LARGE IMMATURE MONONUCLEAR CELLS IN MIXED LEUKOCYTE CULTURES.混合白细胞培养中大型未成熟单核细胞的发育
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LYMPHOCYTE INTERACTION: A POTENTIAL HISTOCOMPATIBILITY TEST IN VITRO.淋巴细胞相互作用：一种潜在的体外组织相容性试验。
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IMMUNE RESPONSE AND MITOSIS OF HUMAN PERIPHERAL BLOOD LYMPHOCYTES IN VITRO.人外周血淋巴细胞在体外的免疫反应与有丝分裂
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体外淋巴细胞转化。3. 混合淋巴细胞培养中的刺激机制。

Lymphocyte transformation in vitro. 3. Mechanism of stimulation in the mixed lymphocyte culture.

作者信息

Schellekens P T, Eijsvoogel V P

出版信息

Clin Exp Immunol. 1970 Aug;7(2):229-39.

PMID:5477932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1712834/
Abstract

In view of the correlation between the mixed lymphocyte culture and the HL-A locus, experiments were performed to determine whether the reactivity in the mixed lymphocyte culture is elicited by the HL-A antigens as such. Fresh lymphocytes were mixed with either allogeneic fibroblasts or allogeneic lymphocytes treated with various metabolic inhibitors or by heating which abolishes their capacity to tranfsorm . No stimulation of the normal untreated lymphocytes was observed in any of these mixed cultures. However, the HL-A antigens 4b and 7b were not affected quantitatively by this treatment as determined serologically. The conclusion is drawn that mixed lymphocyte culture reactivity is not merely a reaction to HL-A antigens, and the consequences of this are discussed.

摘要

鉴于混合淋巴细胞培养与HL - A位点之间的相关性，进行了实验以确定混合淋巴细胞培养中的反应性是否由HL - A抗原本身引发。将新鲜淋巴细胞与同种异体成纤维细胞或用各种代谢抑制剂处理或加热处理（从而消除其转化能力）的同种异体淋巴细胞混合。在任何这些混合培养物中均未观察到对正常未处理淋巴细胞的刺激。然而，通过血清学测定，HL - A抗原4b和7b在数量上不受此处理的影响。得出的结论是，混合淋巴细胞培养反应性不仅仅是对HL - A抗原的反应，并讨论了其后果。