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正常淋巴细胞对培养的淋巴细胞和非淋巴细胞性肿瘤细胞的增殖反应。

Blastogenic response of normal lymphocytes to cultured lymphoid cells and non-lymphoid neoplastic cells.

作者信息

Han T

出版信息

Immunology. 1972 Sep;23(3):355-9.

PMID:4529836
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1407942/
Abstract

Irradiated cultured lymphoid cells (normal and leukaemic) unequivocally stimulated the peripheral lymphocytes from twelve normal individuals. However, irradiated cultured non-lymphoid neoplastic cells (KB cells, melanoma cells and osteogenic sarcoma cells) exerted little or no stimulating effect on lymphocytes of the same donors. These findings indicate that something more than a simple HL-A incompatability is involved in this mixed cell interaction.

摘要

经照射的培养淋巴细胞（正常和白血病性的）明确刺激了12名正常个体的外周淋巴细胞。然而，经照射的培养非淋巴细胞性肿瘤细胞（KB细胞、黑色素瘤细胞和成骨肉瘤细胞）对相同供体的淋巴细胞几乎没有刺激作用。这些发现表明，这种混合细胞相互作用涉及的不仅仅是简单的HL-A不相容性。

相似文献

1
Blastogenic response of normal lymphocytes to cultured lymphoid cells and non-lymphoid neoplastic cells.正常淋巴细胞对培养的淋巴细胞和非淋巴细胞性肿瘤细胞的增殖反应。
Immunology. 1972 Sep;23(3):355-9.
2
Lymphocyte blastogenic responses to cultured allogeneic tumor cells in vitro.体外培养的同种异体肿瘤细胞对淋巴细胞的致有丝分裂反应。
Cancer Res. 1972 May;32(5):988-92.
3
The interaction of normal lymphocytes and cells from lymphoid cell lines. II. Variations relating to cell line source and lymphocyte donor.正常淋巴细胞与淋巴样细胞系细胞的相互作用。II. 与细胞系来源和淋巴细胞供体相关的变异
Immunology. 1970 Aug;19(2):343-51.
4
The interaction of normal lymphocytes and cells from lymphoid cell lines. I. The nature of the activation process.正常淋巴细胞与淋巴样细胞系细胞的相互作用。I. 激活过程的性质。
Immunology. 1970 Aug;19(2):329-42.
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A unique 'leukaemic' T lymphoid cell line: absence of stimulating effect in mixed lymphocyte reaction. Lack of MLR-S in leukaemic T lymphoid cells.一种独特的“白血病性”T淋巴细胞系：在混合淋巴细胞反应中无刺激作用。白血病性T淋巴细胞中缺乏混合淋巴细胞反应刺激因子（MLR-S）
Clin Exp Immunol. 1973 Dec;15(4):535-41.
6
Blastogenic response of lymphocytes separated from bone marrow to allogeneic lymphoid cells in vitro.体外分离自骨髓的淋巴细胞对同种异体淋巴细胞的增殖反应。
Immunology. 1971 Nov;21(5):767-79.
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In vitro culture of human normal and lymphoma cells. Cytochemical study and uptake of labeled nucleic acid precursors.人正常细胞和淋巴瘤细胞的体外培养。细胞化学研究及标记核酸前体的摄取。
Acta Cytol. 1973 May-Jun;17(3):209-13.
8
Stimulation of lymphocytes in vitro to reactions against cultured Burkitt's lymphoma cells.体外刺激淋巴细胞以使其对培养的伯基特淋巴瘤细胞产生反应。
Natl Cancer Inst Monogr. 1973 Jun;37:25-32.
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Evidence for immune reactivity against neoplasms.针对肿瘤的免疫反应性证据。
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Cytotoxicity of lymphocytes to established cultures of human tumors: evidences for specificity.淋巴细胞对人肿瘤已建立培养物的细胞毒性：特异性的证据。
Natl Cancer Inst Monogr. 1973 Jun;37:9-18.

引用本文的文献

1
The interaction of normal lymphocytes and cells from lymphoid cell lines (LCL). V. Cytotoxic properties of activated lymphocytes.正常淋巴细胞与淋巴样细胞系（LCL）细胞的相互作用。V. 活化淋巴细胞的细胞毒性特性。
Immunology. 1974 Feb;26(2):345-58.
2
In vitro preferential effect of irradiation on cultured T lymphoid cell line.辐射对培养的T淋巴细胞系的体外优先效应。
Clin Exp Immunol. 1974 Jul;17(3):455-62.
3
A unique 'leukaemic' T lymphoid cell line: absence of stimulating effect in mixed lymphocyte reaction. Lack of MLR-S in leukaemic T lymphoid cells.一种独特的“白血病性”T淋巴细胞系：在混合淋巴细胞反应中无刺激作用。白血病性T淋巴细胞中缺乏混合淋巴细胞反应刺激因子（MLR-S）
Clin Exp Immunol. 1973 Dec;15(4):535-41.
4
Human myeloma cells and their strong stimulating capacity in 'one-way' mixed lymphocyte reaction: a comparative study with leukaemic B lymphoid cells.人骨髓瘤细胞及其在“单向”混合淋巴细胞反应中的强刺激能力：与白血病B淋巴细胞的比较研究
Immunology. 1979 Sep;38(1):63-8.
5
Stimulating capacity of fresh and cultured human leukaemic lymphoid and myeloid cells in 'one-way' mixed lymphocyte reaction.新鲜及培养的人白血病淋巴和髓细胞在“单向”混合淋巴细胞反应中的刺激能力
Immunology. 1977 Oct;33(4):543-51.
6
Human mixed lymphocyte culture using separated lymphocyte populations.使用分离淋巴细胞群体的人混合淋巴细胞培养。
Immunology. 1977 Mar;32(3):359-65.

本文引用的文献

1
Exceptional lymphocyte stimulating capacity of cells from lymphoid cell lines.来自淋巴样细胞系的细胞具有非凡的淋巴细胞刺激能力。
Nature. 1969 Aug 2;223(5205):511-2. doi: 10.1038/223511a0.
2
Effects of some cellular antigens on lymphocytes and the nature of the mixed lymphocyte reaction.
Nature. 1969 Feb 8;221(5180):545-8. doi: 10.1038/221545a0.
3
The interaction of normal lymphocytes and cells from lymphoid cell lines. II. Variations relating to cell line source and lymphocyte donor.正常淋巴细胞与淋巴样细胞系细胞的相互作用。II. 与细胞系来源和淋巴细胞供体相关的变异
Immunology. 1970 Aug;19(2):343-51.
4
In vitro lymphocyte response to autologous cultured lymphoid cells.体外淋巴细胞对自体培养淋巴细胞的反应。
Proc Soc Exp Biol Med. 1971 Mar;136(3):976-9. doi: 10.3181/00379727-136-35409.
5
The life span of the cultured normal cell: concepts derived from studies of human lymphoblasts.培养的正常细胞的寿命：源自人类淋巴母细胞研究的概念。
J Theor Biol. 1968 Aug;20(2):217-26. doi: 10.1016/0022-5193(68)90191-4.