Miller I J
J Gen Physiol. 1971 Jan;57(1):1-25. doi: 10.1085/jgp.57.1.1.
Recordings were made from single fibers of the rat chorda tympani nerve while the peripheral receptor fields were mapped using a stimulator developed to stimulate single fungiform papillae which in the rat contain a solitary taste bud. The results indicate that several fungiform papillae may supply input to a single fiber, and the most sensitive papilla of these provided, on the average, about one-half of the response of that fiber to stimulation of the entire tongue. The magnitude of the response to each concentration of stimulus and the shape of the concentration-response curves differ among papillae innervated by the same fiber. If one of the papillae supplying input to the fiber was stimulated individually with NaCl solution, application of this stimulus to the tongue surface surrounding the isolated papilla resulted in enhancement of the fiber response. If the papilla was stimulated with NaCl and potassium benzoate solution was applied to the surround, a depression of the response occurred. The excitatory input of the cationic stimuli and the depressing influence of the anionic stimuli interacted to determine the resultant steady-state impulse frequency of the single afferent fiber. A hypothetical model involving the summation of generator currents along the unmyelinated terminals of the single afferent neuron is presented as a speculative explanation of the integration of inputs from several receptors innervated by the same single fiber.
在使用一种专门开发的刺激器绘制大鼠鼓索神经单纤维记录时，该刺激器用于刺激单个菌状乳头，而大鼠的菌状乳头中含有单个味蕾。结果表明，几个菌状乳头可能为单根纤维提供输入，并且这些乳头中最敏感的乳头平均提供了该纤维对整个舌头刺激反应的约一半。同一根纤维支配的乳头对每种刺激浓度的反应大小以及浓度-反应曲线的形状各不相同。如果用氯化钠溶液单独刺激为该纤维提供输入的一个乳头，将此刺激施加到孤立乳头周围的舌表面会导致纤维反应增强。如果用氯化钠刺激乳头并将苯甲酸钾溶液施加到周围区域，则会出现反应抑制。阳离子刺激的兴奋性输入和阴离子刺激的抑制作用相互作用，以确定单个传入纤维的最终稳态冲动频率。提出了一个假设模型，该模型涉及沿单个传入神经元无髓鞘终末的发生器电流总和，作为对同一根单纤维支配的多个感受器输入整合的推测性解释。
