溃疡性结肠炎伴癌前病变时乳酸脱氢酶同工酶谱异常。
Abnormal lactic dehydrogenase isoenzyme patterns in ulcerative colitis with precancerous change.
作者信息
Lewis B, Morson B C, February A W, Jones J H, Misiewicz J J
出版信息
Gut. 1971 Jan;12(1):16-9. doi: 10.1136/gut.12.1.16.
Abstract
The isoenzyme pattern of lactic dehydrogenase was measured in rectal biopsies from six patients with ulcerative colitis in whom precancerous histological changes had been independently recognized. There was a highly significant increase in the ratio of isoenzymes IV + V to I + II. This suggests that lactic dehydrogenase isoenzyme measurement may prove a valuable addition to histology in the recognition of precancer in ulcerative colitis.
摘要
对6例溃疡性结肠炎患者的直肠活检组织进行乳酸脱氢酶同工酶谱检测，这些患者均已被独立确认存在癌前组织学改变。同工酶IV + V与I + II的比值显著升高。这表明，在溃疡性结肠炎癌前病变的识别中，乳酸脱氢酶同工酶检测可能是组织学检查的一项有价值的补充。
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