Stockdale F E
Science. 1971 Mar 19;171(3976):1145-7. doi: 10.1126/science.171.3976.1145.
As skeletal muscle cells differentiate, they fail to initiate DNA synthesis. This rigid regulation, which persists even after cells are fully developed, does not extend to "repair" DNA synthesis, in that ultraviolet light initiates DNA synthesis in 99 percent of the muscle nuclei exposed. The rate of "repair" DNA synthesis in these nuclei, however, drops over 50 percent at the time of cell differentiation.
随着骨骼肌细胞分化，它们无法启动DNA合成。这种严格的调控即使在细胞完全发育后仍持续存在，但并不适用于“修复”性DNA合成，因为紫外线可使99%暴露的肌细胞核启动DNA合成。然而，在细胞分化时，这些细胞核中“修复”性DNA合成的速率下降超过50%。
