Oliva A, Cacciapuoti G, Romeo G, Porcelli M
Boll Soc Ital Biol Sper. 1979 Oct 15;55(19):2019-24.
The paper reports the preparation and the chromatographic separation of new deaminated analogs of S-adenosyl(5')-3-methylthiopropylamine, i.e. S-adenosyl(5')-3-methylthiopropanol and S-inosyl(5')(-3-methylthiopropanol. These compounds can be used as specific inhibitors of polyamine biosynthesis. It is also reported the characterization of new sulfonium compounds by U.V. spectrophotometry, thin layer chromatography, high voltage electrophoresis, hydrolysis to known fragments.
该论文报道了S-腺苷基(5')-3-甲硫基丙胺的新型脱氨基类似物，即S-腺苷基(5')-3-甲硫基丙醇和S-肌苷基(5')-3-甲硫基丙醇的制备及色谱分离。这些化合物可用作多胺生物合成的特异性抑制剂。还通过紫外分光光度法、薄层色谱法、高压电泳法以及水解为已知片段对新型锍化合物进行了表征。
