Pescarmona G P, Sartori M L, Bosia A
Boll Soc Ital Biol Sper. 1979 Apr 30;55(8):809-15.
G6PD, GSH-Px and 6PGD activity was found to be elevated in beta-thalassemia heterozygous erythrocytes. Estimates of the activities of the three enzymes in red cell fractions of differing mean age separated by centrifugation through a density gradient of Ficoll-Triosil layers, showed that the rate of in vivo decline was normal for G6PD and GSH-Px, and decreased for 6PGD. The increased enzyme activity results from increased rate of synthesis for G6PD and GSH-Px, and from higher in vivo stability for 6PGD.
研究发现，β地中海贫血杂合子红细胞中的葡萄糖-6-磷酸脱氢酶（G6PD）、谷胱甘肽过氧化物酶（GSH-Px）和6-磷酸葡萄糖酸脱氢酶（6PGD）活性升高。通过在Ficoll-三碘苯甲酸盐层密度梯度中离心分离不同平均年龄的红细胞组分，对这三种酶的活性进行评估，结果显示G6PD和GSH-Px的体内下降速率正常，而6PGD的下降速率降低。酶活性增加是由于G6PD和GSH-Px的合成速率增加，以及6PGD在体内具有更高的稳定性。
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