中国仓鼠卵巢细胞嘌呤突变体的新类别。
New class of purine mutants of Chinese hamster ovary cells.
作者信息
Taylor M W, Souhrada M, McCall J
出版信息
Science. 1971 Apr 9;172(3979):162-3. doi: 10.1126/science.172.3979.162.
PMID:5547727
Abstract
Mutants of Chinese hamster ovary cells (CHO/Pro(-)) were isolated after mutagenesis with N-methylnitrosoguanidine and selection by the bromodeoxyuridine technique. Six of these were mutants classified as purine-requiring. The metabolic block appears to be early in the purine biosynthetic pathway. The mutants do not appear to be genetically identical.
摘要
用N-甲基亚硝基胍诱变并通过溴脱氧尿苷技术筛选后，分离出了中国仓鼠卵巢细胞（CHO/Pro(-)）的突变体。其中六个是被归类为需要嘌呤的突变体。代谢阻断似乎发生在嘌呤生物合成途径的早期。这些突变体似乎在基因上并不相同。
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