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中国仓鼠卵巢细胞嘌呤突变体的新类别。

New class of purine mutants of Chinese hamster ovary cells.

作者信息

Taylor M W, Souhrada M, McCall J

出版信息

Science. 1971 Apr 9;172(3979):162-3. doi: 10.1126/science.172.3979.162.

DOI:10.1126/science.172.3979.162
PMID:5547727
Abstract

Mutants of Chinese hamster ovary cells (CHO/Pro(-)) were isolated after mutagenesis with N-methylnitrosoguanidine and selection by the bromodeoxyuridine technique. Six of these were mutants classified as purine-requiring. The metabolic block appears to be early in the purine biosynthetic pathway. The mutants do not appear to be genetically identical.

摘要

用N-甲基亚硝基胍诱变并通过溴脱氧尿苷技术筛选后，分离出了中国仓鼠卵巢细胞（CHO/Pro(-)）的突变体。其中六个是被归类为需要嘌呤的突变体。代谢阻断似乎发生在嘌呤生物合成途径的早期。这些突变体似乎在基因上并不相同。

相似文献

1
New class of purine mutants of Chinese hamster ovary cells.中国仓鼠卵巢细胞嘌呤突变体的新类别。
Science. 1971 Apr 9;172(3979):162-3. doi: 10.1126/science.172.3979.162.
2
Biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism: biochemical analysis of eight mutants.具有异常嘌呤代谢的中国仓鼠细胞突变体的生化遗传学：八个突变体的生化分析
Somatic Cell Genet. 1975 Jan;1(1):91-110. doi: 10.1007/BF01538734.
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Genetics of somatic mammalian cells, VII. Induction and isolation of nutritional mutants in Chinese hamster cells.哺乳动物体细胞遗传学，VII. 中国仓鼠细胞中营养缺陷型突变体的诱导与分离
Proc Natl Acad Sci U S A. 1968 Aug;60(4):1275-81. doi: 10.1073/pnas.60.4.1275.
4
Biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism: isolation and characterization of a mutant deficient in the activity of phosphoribosylaminoimidazole synthetase.具有异常嘌呤代谢的中国仓鼠细胞突变体的生化遗传学：磷酸核糖氨基咪唑合成酶活性缺陷突变体的分离与鉴定
Somatic Cell Genet. 1979 Mar;5(2):203-16. doi: 10.1007/BF01539161.
5
[Candida guilliermondii mutants with blocked catabolism of purines and flavinogenic activity of these mutants].[吉列蒙念珠菌嘌呤分解代谢受阻的突变体及其黄素生成活性]
Mikrobiologiia. 1971 Nov-Dec;40(6):1070-6.
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Purine mutants of mammalian cell lines. I. Accumulation of formylglycinamide ribotide by purine mutants of Chinese hamster ovary cells.哺乳动物细胞系的嘌呤突变体。I. 中国仓鼠卵巢细胞嘌呤突变体对甲酰甘氨酰胺核苷酸的积累
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Genetic and metabolomic analysis of AdeD and AdeI mutants of de novo purine biosynthesis: cellular models of de novo purine biosynthesis deficiency disorders.从头嘌呤生物合成中 AdeD 和 AdeI 突变体的遗传和代谢组学分析：从头嘌呤生物合成缺陷疾病的细胞模型。
Mol Genet Metab. 2013 Mar;108(3):178-189. doi: 10.1016/j.ymgme.2013.01.002. Epub 2013 Jan 12.
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Mammalian cell genetics. II. Chemical induction of specific locus mutations in Chinese hamster cells in vitro.哺乳动物细胞遗传学。II. 体外化学诱导中国仓鼠细胞特定基因座突变
Proc Natl Acad Sci U S A. 1968 Dec;61(4):1306-12. doi: 10.1073/pnas.61.4.1306.
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The action of Mendelian genes in human diploid cell strains.孟德尔基因在人类二倍体细胞株中的作用。
J Cell Physiol. 1970 Dec;76(3):311-30. doi: 10.1002/jcp.1040760310.
10
The response of Chinese hamster cells to N-methyl-N'-nitro-N-nitrosoguanidine.
Mutat Res. 1971 Apr;11(4):421-9.

引用本文的文献

1
Cellular reactions of O6-methylguanine, a product of some alkylating carcinogens.某些烷基化致癌物的产物O6-甲基鸟嘌呤的细胞反应。
Biochem J. 1973 Oct;136(2):387-93. doi: 10.1042/bj1360387.
2
Induction and analysis of gene mutations in cultured mammalian somatic cells.培养的哺乳动物体细胞中基因突变的诱导与分析。
Genetics. 1974 Sep;78(1):115-32. doi: 10.1093/genetics/78.1.115.
3
Genetics of somatic mammalian cells: biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism.哺乳动物体细胞遗传学：嘌呤代谢异常的中国仓鼠细胞突变体的生化遗传学
Proc Natl Acad Sci U S A. 1974 May;71(5):2057-61. doi: 10.1073/pnas.71.5.2057.
4
Induction of auxotrophic mutations by treatment of Chinese hamster cells with 5-bromodeoxyuridine and black light.用5-溴脱氧尿苷和黑光处理中国仓鼠细胞诱导营养缺陷型突变
Proc Natl Acad Sci U S A. 1972 Nov;69(11):3459-63. doi: 10.1073/pnas.69.11.3459.
5
Purine mutants of mammalian cell lines. I. Accumulation of formylglycinamide ribotide by purine mutants of Chinese hamster ovary cells.哺乳动物细胞系的嘌呤突变体。I. 中国仓鼠卵巢细胞嘌呤突变体对甲酰甘氨酰胺核苷酸的积累
Biochem Genet. 1974 Nov;12(5):393-405. doi: 10.1007/BF00486644.
6
Utilization of somatic cell hybrids for genetic studies in man.利用体细胞杂种进行人类遗传学研究。
Humangenetik. 1973;19(1):1-40. doi: 10.1007/BF00295233.
7
5-bromodeoxyuridine-DNA strand symmetry and the repair of photolytic breaks in Chinese hamster cell chromosomes.5-溴脱氧尿苷-DNA链对称性与中国仓鼠细胞染色体中光解断裂的修复
Proc Natl Acad Sci U S A. 1976 Nov;73(11):3905-9. doi: 10.1073/pnas.73.11.3905.