胃酸分泌抑制剂尿抑胃素的制备与测定
Preparation and assay of urogastrone, an inhibitor of gastric acid secretion.
作者信息
Lawrence A J, Schild H O, Smith G M
出版信息
Br J Pharmacol. 1971 Jan;41(1):8-18. doi: 10.1111/j.1476-5381.1971.tb09930.x.
Abstract
- Urogastrone, an acid gastric secretion inhibitor extracted from human urine, was assayed in the anaesthetized rat by circulating through its stomach a succinic-propionic buffer and recording electrometrically the secretion of acid in response to carbachol, and inhibition of carbachol secretion by urogastrone.2. Quantitative assay procedures are described requiring the administration of only one or two doses of urogastrone to each rat.3. An extraction procedure for urogastrone is described based on the use of zeocarb, a cationic polystyrene resin.4. The most purified samples contained 40-80 times the amount/milligram which was just detectable by the assay method.
摘要
尿抑胃素是一种从人尿中提取的胃酸分泌抑制剂，在麻醉大鼠中进行测定时，通过让琥珀酸 - 丙酸缓冲液循环流经其胃部，并以电测法记录对卡巴胆碱的胃酸分泌以及尿抑胃素对卡巴胆碱分泌的抑制作用。
描述了定量测定程序，每只大鼠只需给予一或两剂尿抑胃素。
描述了一种基于使用阳离子聚苯乙烯树脂“争光树脂”的尿抑胃素提取程序。
最纯的样品每毫克所含的量是测定方法刚能检测到的量的40 - 80倍。
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Preparation and assay of urogastrone, an inhibitor of gastric acid secretion.胃酸分泌抑制剂尿抑胃素的制备与测定
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本文引用的文献
1
INHIBITION OF GASTRIC SECRETION BY EXTRACTS OF NORMAL MALE URINE.正常男性尿液提取物对胃酸分泌的抑制作用。
Science. 1939 May 26;89(2317):489-90. doi: 10.1126/science.89.2317.489.
2
The assay of urogastrone.尿抑胃素的测定
J Physiol. 1962 Jun;162(1):155-62. doi: 10.1113/jphysiol.1962.sp006922.
3
The preparation of urogastrone.尿抑胃素的制备。
J Physiol. 1962 Jun;162(1):163-72. doi: 10.1113/jphysiol.1962.sp006923.
4
Continuous recording of acid gastric secretion in the rat.大鼠胃酸分泌的连续记录。
Br J Pharmacol Chemother. 1958 Mar;13(1):54-61. doi: 10.1111/j.1476-5381.1958.tb00190.x.
5
A new method for the preparation of urogastrone.一种制备尿抑胃素的新方法。
J Physiol. 1955 Sep 28;129(3):528-46. doi: 10.1113/jphysiol.1955.sp005375.
6
The effect of urogastrone, enterogastrone and mepyramine maleate on gastric and pancreatic secretion.尿抑胃素、肠抑胃素及马来酸美吡拉敏对胃和胰腺分泌的影响。
J Physiol. 1954 Jan;123(1):1-15. doi: 10.1113/jphysiol.1954.sp005029.
7
The assay of gastrin using the perfused rat stomach.使用灌注大鼠胃进行胃泌素测定。
Br J Pharmacol. 1970 Jan;38(1):206-13.
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