Korth H, Pulverer G
Appl Microbiol. 1971 Mar;21(3):541-2. doi: 10.1128/am.21.3.541-542.1971.
When 2,3- or 3,4-dihydroxybenzoic acid, 3,4-dihydroxyphenylalanine, and 3,4-dihydroxycinnamic acid are added to growth media, they are converted to a characteristic brown pigment by Cryptococcus neoformans. This pigment formation has hitherto been encountered only when this microorganism was cultivated on media containing Guizotia abyssinica seed. This phenomenon can be used for differentiating Cryptococcus neoformans from Candida albicans. Possible precursors of these o-diphenols (quinic acid, aromatic monohydroxy acids, or tyrosine) do not give rise to the brown pigmentation.
当将2,3 - 或3,4 - 二羟基苯甲酸、3,4 - 二羟基苯丙氨酸和3,4 - 二羟基肉桂酸添加到生长培养基中时,新型隐球菌会将它们转化为一种特征性的棕色色素。迄今为止,只有当这种微生物在含有埃塞俄比亚画眉草种子的培养基上培养时,才会出现这种色素形成现象。这种现象可用于区分新型隐球菌和白色念珠菌。这些邻二酚的可能前体(奎尼酸、芳香单羟基酸或酪氨酸)不会产生棕色色素沉着。