黑色素在黑色真菌中的抗氧化功能。
Antioxidant function of melanin in black fungi.
作者信息
Jacobson E S, Hove E, Emery H S
机构信息
McGuire Veterans Affairs Medical Center, Richmond, Virginia, USA.
出版信息
Infect Immun. 1995 Dec;63(12):4944-5. doi: 10.1128/iai.63.12.4944-4945.1995.
Abstract
1,8-Dihydroxynaphthalene melanin in Wangiella dermatitidis and Alternaria alternata was titrated in vivo with the oxidants permanganate, hypochlorite, and H2O2. Melanized strains neutralized more oxidant and withstood higher concentrations of permanganate and hypochlorite than albino strains did. H2O2 killing required 1,000-fold higher concentrations, and melanin did not protect W. dermatitidis against H2O2.
摘要
用氧化剂高锰酸盐、次氯酸盐和过氧化氢对皮炎万吉拉霉和链格孢中的1,8 - 二羟基萘黑色素进行体内滴定。与白化菌株相比，黑色素化菌株中和了更多的氧化剂，并且能耐受更高浓度的高锰酸盐和次氯酸盐。过氧化氢杀菌所需浓度要高1000倍，黑色素并不能保护皮炎万吉拉霉免受过氧化氢的伤害。
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本文引用的文献
1
The free radical property of melanins.
Arch Biochem Biophys. 1960 Feb;86:225-30. doi: 10.1016/0003-9861(60)90409-4.
2
Gene cluster involved in melanin biosynthesis of the filamentous fungus Alternaria alternata.
J Bacteriol. 1993 Jul;175(14):4427-35. doi: 10.1128/jb.175.14.4427-4435.1993.
3
Antioxidant function of fungal melanin.
J Bacteriol. 1993 Nov;175(21):7102-4. doi: 10.1128/jb.175.21.7102-7104.1993.
4
Susceptibility of melanized and nonmelanized Cryptococcus neoformans to nitrogen- and oxygen-derived oxidants.
Infect Immun. 1994 Jul;62(7):3004-7. doi: 10.1128/iai.62.7.3004-3007.1994.
5
Cryptococcus neoformans melanin and virulence: mechanism of action.
Infect Immun. 1995 Aug;63(8):3131-6. doi: 10.1128/iai.63.8.3131-3136.1995.
6
Melanin-lacking mutants of Cryptococcus neoformans and their virulence for mice.
J Bacteriol. 1982 Jun;150(3):1414-21. doi: 10.1128/jb.150.3.1414-1421.1982.
7
Pentaketide metabolites of melanin synthesis in the dematiaceous fungus Wangiella dermatitidis.
Arch Microbiol. 1984 Apr;137(4):324-8. doi: 10.1007/BF00410729.
8
Hydrogen peroxide metabolism in human monocytes during differentiation in vitro.
J Clin Invest. 1981 Nov;68(5):1243-52. doi: 10.1172/jci110370.
9
Pigment formation for differentiating Cryptococcus neoformans from Candida albicans.
Appl Microbiol. 1971 Mar;21(3):541-2. doi: 10.1128/am.21.3.541-542.1971.
10
A study of the oxidation-reduction state of synthetic 3,4-dihydroxy-DL-phenylalanine melanin.
Mol Pharmacol. 1971 Jul;7(4):429-33.
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