Hishon S, Lovell D, Gummer J W, Smithies A, Shawdon H, Blendis L M
Lancet. 1976 Feb 7;1(7954):296-7. doi: 10.1016/s0140-6736(76)91417-3.
The value of brush cytology under direct vision in the diagnosis of oesophageal cancer was evaluated and compared with other diagnostic procedures in a prospective study of 33 patients suspected of having an oesophageal lesion. Barium swallow correctly diagnosed cancer in 19 out of 20 patients, the remaining patient was diagnosed by both histology and cytology. In all, cytology was correct in 18 cases (90%), whereas histology confirmed the diagnosis in 10 (50%). In the 13 patients with benign lesions, barium swallow was correct in 12; cytology was benign in all 13; biopsy was only possible in 9, although the results of this procedure were always correct. Thus barium swallow is still the ideal screening procedure for patients with oesophageal symptoms, but per-endoscopic brush cytology seems to be the method of choice for confirmation of the diagnosis.
在一项对33例疑似食管病变患者的前瞻性研究中，评估了直视下刷检细胞学在食管癌诊断中的价值，并与其他诊断方法进行了比较。20例患者中，食管钡餐正确诊断出19例癌症，其余1例患者通过组织学和细胞学检查确诊。总体而言，细胞学检查在18例中正确（90%），而组织学确诊10例（50%）。在13例良性病变患者中，食管钡餐检查正确12例；13例细胞学检查均为良性；活检仅在9例中可行，尽管该检查结果总是正确的。因此，食管钡餐仍然是有食管症状患者的理想筛查方法，但内镜下刷检细胞学似乎是确诊的首选方法。
