George J M
Science. 1978 Apr 21;200(4339):342-3. doi: 10.1126/science.556308.
Individual hypothalamic nuclei were microdissected from brain tissue of ten human subjects who had died suddenly while in apparent good health. Appreciable amounts of vasopressin and oxytocin immunoreactivity were found by specific radioimmunoassay in six hypothalamic nuclei including supraoptic and paraventricular nuclei. Vasopressin and oxytocin are presumed to be synthesized in supraoptic and paraventricular nuclei for axonal transport to the posterior pituitary for storage and release. Vasopressin and oxytocin in other hypothalamic nuclei may be a part of this system of neurosecretion or may serve some other function.
从十名看似健康却突然死亡的人类受试者的脑组织中显微解剖出各个下丘脑核。通过特异性放射免疫测定法在包括视上核和室旁核在内的六个下丘脑核中发现了可观量的加压素和催产素免疫反应性。加压素和催产素被推测在视上核和室旁核中合成，通过轴突运输至垂体后叶储存和释放。其他下丘脑核中的加压素和催产素可能是这个神经分泌系统的一部分，或者可能具有其他功能。
