Gemmell R T, Stacy R D
J Reprod Fertil. 1977 Jan;49(1):115-7. doi: 10.1530/jrf.0.0490115.
By 4 h after i.v. injection of ewes at the mid-luteal phase of the oestrous cycle with colchicine (1 mg/kg), the concentration of progesterone in peripheral plasma was halved while the content of progesterone in luteal tissue was doubled. The ultrastructure of the luteal tissue showed some specific drug-induced changes: microtubules were no longer present and the intracellular transport and secretion of granules associated with progesterone secretion appeared to be inhibited.
在发情周期的黄体中期，给母羊静脉注射秋水仙碱（1毫克/千克）后4小时，外周血浆中孕酮浓度减半，而黄体组织中孕酮含量翻倍。黄体组织的超微结构显示出一些特定的药物诱导变化：微管不再存在，与孕酮分泌相关的颗粒的细胞内运输和分泌似乎受到抑制。
