放线菌酮对绵羊黄体的影响：颗粒在孕酮分泌中的作用。
Effect of cycloheximide on the ovine corpus luteum: the role of granules in the secretion of progesterone.
作者信息
Gemmell R T, Stacy B D
出版信息
J Reprod Fertil. 1979 Sep;57(1):87-9. doi: 10.1530/jrf.0.0570087.
PMID:513010
Abstract
Cycloheximide (3 mg/h) was infused into the corpus luteum of the sheep via a side branch of the ovarian artery. The concentration of progesterone in the peripheral plasma and the luteal tissue decreased after the infusion. Ultrastructural studies showed that cycloheximide caused inhibition of the formation and secretion of densely stained granules in the luteal cells. The results provide further evidence that progesterone bound to protein is secreted by the luteal cell in the form of granules.
摘要
通过卵巢动脉的一个分支将放线菌酮（3毫克/小时）注入绵羊的黄体。注入后外周血浆和黄体组织中的孕酮浓度降低。超微结构研究表明，放线菌酮会抑制黄体细胞中深色颗粒的形成和分泌。这些结果进一步证明，与蛋白质结合的孕酮是以颗粒的形式由黄体细胞分泌的。
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