麻醉诱导的恶性高热：一种建议的治疗方法。
Anaesthetic-induced malignant hyperpyrexia: a suggested method of treatment.
作者信息
Harrison G G
出版信息
Br Med J. 1971 Aug;3(5772):454-6. doi: 10.1136/bmj.3.5772.454.
Abstract
Experiments in susceptible Landrace pigs have shown that procaine blocks the initiation of anaesthetic-induced malignant hyperpyrexia by both halothane and succinylcholine. Pretreatment with curare prevents only the trigger action of succinylcholine. In a preliminary study procaine was used to treat the established syndrome in five pigs, two of which survived. On the basis of these findings a treatment regimen can be suggested for patients who develop malignant hyperpyrexia.
摘要
在易患恶性高热的长白猪身上进行的实验表明，普鲁卡因可阻止氟烷和琥珀酰胆碱引发麻醉诱导的恶性高热。箭毒预处理仅能防止琥珀酰胆碱的触发作用。在一项初步研究中，使用普鲁卡因治疗了5头猪的已确诊综合征，其中2头存活。基于这些发现，可为发生恶性高热的患者提出一种治疗方案。
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