Blitt C D, Petty W C, Alberternst E E, Wright B J
Anesth Analg. 1977 Jan-Feb;56(1):78-83. doi: 10.1213/00000539-197701000-00019.
Correlation between plasma cholinesterase activity and duration of neuromuscular blockade following succinylcholine (SCh) was studied in 30 healthy women undergoing laparoscopic tubal coagulation and 20 pregnany women indergoing elective repeat cesarean section. All patients received N2O-thiopental anesthesia. Cholinesterase activity in nonpregnant patients was significantly greater than in pregnant patients. Time to 90 percent recovery of control twitch height following 40 or 80 mg/m2 BSA of SCh was not significantly different in pregnant versus nonpregnant patients. There also was no correlation between plasma cholinesterase activity and duration of paralysis from SCh. The authors conclude that pregnant patients have lower cholinesterase activity, but prolonged neuromuscular blockade from SCh should not occur unless the patient is grossly overdosed with SCh. Routine use of a peripheral nerve stimulator is recommended to avoid such overdosage.
在30名接受腹腔镜输卵管凝固术的健康女性和20名接受择期再次剖宫产的孕妇中，研究了琥珀酰胆碱（SCh）后血浆胆碱酯酶活性与神经肌肉阻滞持续时间之间的相关性。所有患者均接受N2O - 硫喷妥钠麻醉。非孕患者的胆碱酯酶活性显著高于孕患者。给予40或80mg/m2体表面积的SCh后，孕患者与非孕患者恢复至对照抽搐高度90%的时间无显著差异。血浆胆碱酯酶活性与SCh所致麻痹持续时间之间也无相关性。作者得出结论，孕患者胆碱酯酶活性较低，但除非患者SCh严重过量，否则不应出现SCh所致的神经肌肉阻滞延长。建议常规使用外周神经刺激器以避免此类过量。
