前列腺素与青光眼
Prostaglandins and glaucoma.
作者信息
Wyllie A M, Wyllie J H
出版信息
Br Med J. 1971 Sep 11;3(5775):615-7. doi: 10.1136/bmj.3.5775.615.
Abstract
Human aqueous humour was found to contain a substance which contracted the rat stomach strip. The mean activity was significantly higher in specimens from open angle glaucoma cases than in specimens from patients with cataract. The pharmacological and chromatographic properties of the active material were studied in aqueous humour obtained from cadavers; activity seemed to be due to prostaglandin E(1). These results suggest that prostaglandin E(1) may play some part in the aetiology of open angle glaucoma.
摘要
研究发现，人房水中含有一种能使大鼠胃条收缩的物质。开角型青光眼患者样本中的平均活性显著高于白内障患者样本。对从尸体获取的房水中的活性物质进行了药理和色谱特性研究；活性似乎归因于前列腺素E(1)。这些结果表明，前列腺素E(1)可能在开角型青光眼的病因学中起一定作用。
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