（2-羟基-1-萘基）-甲基氨基乙酰氨基-表青霉素和头孢拉定以及（2-羟基-1-萘基）-甲基乙酰氨基6-氨基青霉烷酸的合成与生物活性
Synthesis and biological activity of (2-hydroxy-1-naphthyl)-methylamino acetamido-epicillin and cephradine, and (2-hydroxy-1-naphthyl)-methylacetamido 6-APA.
作者信息
Ryu D D, Mukherjee B B, Lee B K
出版信息
J Antibiot (Tokyo). 1977 Jan;30(1):66-70. doi: 10.7164/antibiotics.30.66.
PMID:557033
Abstract
Two new penicillins and a new cephalosporin have been synthesized by condensing 2-hydroxy-1-naphthaldehyde with epicillin, 6-aminopenicillanic acid and cephradine, and subsequently reducing the SCHIFF bases with NaBH4. The antimicrobial activities of these compounds are also described.
摘要
通过将2-羟基-1-萘甲醛与表霉素、6-氨基青霉烷酸和头孢拉定缩合，随后用硼氢化钠还原席夫碱，合成了两种新的青霉素和一种新的头孢菌素。还描述了这些化合物的抗菌活性。
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