Hashem A I, Shaban M E, Abdel-Aziz R, Abdel-Nasser G
Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Arch Pharm (Weinheim). 1998 Sep;331(9):294-6. doi: 10.1002/(sici)1521-4184(19989)331:9<294::aid-ardp294>3.0.co;2-f.
A dihydroampicillin (3) and a dihydrocephalexin (4) have been synthesized by condensing alpha-(cyclohexa-1, 3-dienyl)glycyl chloride with 6-aminopenicillanic acid (1) and 7-deacetoxycephalosporanic acid (2) respectively. The two antibiotics obtained show enhanced antimicrobial activity towards certain bacterial strains compared with ampicillin and cephalexin.
