Phelan J P, Meguiar R V, Matey D, Newman C
Am J Obstet Gynecol. 1978 Sep 1;132(1):28-32. doi: 10.1016/0002-9378(78)90793-7.
The efficacy of prostaglandin E2 (PGE2) for the induction of labor in pregnancies complicated by IUFD or missed abortion has been demonstrated. Gastrointestinal and pyrexic side effects are frequently observed. The following report describes two patients with documented IUFD who experienced a dramatic pyrexic and cardiovascular response to the intravaginal PGE2. In addition, evidence will be provided to account for this unusual pharmacologic reaction, as well as provide a method of managing this unusual side effect.
前列腺素E2（PGE2）用于引产治疗合并胎死宫内或稽留流产的妊娠的疗效已得到证实。胃肠道和发热副作用较为常见。以下报告描述了两名记录为胎死宫内的患者，她们对阴道内使用PGE2出现了显著的发热和心血管反应。此外，将提供证据解释这种异常的药理反应，并提供一种处理这种异常副作用的方法。
