Mikes F, Waser P G
Science. 1971 Jun 11;172(3988):1158-9. doi: 10.1126/science.172.3988.1158.
Cigarettes impregnated with various preparations of Delta(9)-tetrahydro-cannabinol (Delta(9)-THC) and cannabidiol were artificially smoked, and the smoke was analyzed by means of gas chromatography and a combination of gas chromatography and mass spectrometry. Retention of the two test substances in smoke was 21 to 23 percent of the starting amount. The ratio of Delta(9)-THC to cannabidiol in smoke is different from that in starting material. It is suggested that these differences are the result of partial cyclization of the cannabidiol to Delta(9)-THC. An increase in the percentage of cannabinol in smoke is the result of a partial dehydrogenation drogenation of Delta(9)-THC or cannabidiol. No evidence for the isomerization of Delta(9)-THC to Delta(8)-THC or for the formation of new pyrolyzed products was found.
将含有各种Δ⁹-四氢大麻酚（Δ⁹-THC）和大麻二酚制剂的香烟进行人工抽吸，并通过气相色谱法以及气相色谱-质谱联用分析法对烟雾进行分析。两种受试物质在烟雾中的残留量为起始量的21%至23%。烟雾中Δ⁹-THC与大麻二酚的比例与起始原料中的不同。据推测，这些差异是大麻二酚部分环化生成Δ⁹-THC的结果。烟雾中大麻酚百分比的增加是Δ⁹-THC或大麻二酚部分脱氢的结果。未发现Δ⁹-THC异构化为Δ⁸-THC或形成新的热解产物的证据。
