电压钳制下分离神经胞体中的内向和延迟外向膜电流。
Inward and delayed outward membrane currents in isolated neural somata under voltage clamp.
作者信息
Connor J A, Stevens C F
出版信息
J Physiol. 1971 Feb;213(1):1-19. doi: 10.1113/jphysiol.1971.sp009364.
Abstract
- Membrane current-voltage relationships were investigated under voltage clamp conditions in isolated neural somata of marine gastropods.2. Step depolarizations from the resting potential produce an initial inward current followed by a delayed outward current.3. Inward current appears to be carried by both sodium and calcium ions and displays time and voltage dependent properties similar to those of other excitable membranes.4. Activation and deactivation of the delayed outward current follow a more complicated time course than that of a single exponential raised to a power but can be fitted by the product of two exponential functions.5. Delayed outward current inactivation proceeds with a time constant which decreases as membrane voltage is made more positive. The steady-state levels of inactivation as a function of membrane voltage are related by an S-shaped curve similar to that for K inactivation in squid giant axon.
摘要
在电压钳制条件下，对海洋腹足纲动物分离的神经细胞体的膜电流-电压关系进行了研究。
从静息电位进行的阶跃去极化产生一个初始内向电流，随后是延迟外向电流。
内向电流似乎由钠离子和钙离子共同携带，并表现出与其他可兴奋膜相似的时间和电压依赖性特性。
延迟外向电流的激活和失活遵循比单个指数幂更复杂的时间进程，但可以用两个指数函数的乘积来拟合。
延迟外向电流失活的时间常数随着膜电压更正而减小。失活的稳态水平作为膜电压的函数，通过与鱿鱼巨轴突中钾离子失活相似的S形曲线相关联。
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