心脏浦肯野纤维膜电容的频率依赖性特征。
The frequency dependent character of the membrane capacity in cardiac Purkynĕ fibres.
作者信息
Carmeliet E, Willems J
出版信息
J Physiol. 1971 Feb;213(1):85-93. doi: 10.1113/jphysiol.1971.sp009369.
Abstract
- The upstroke of the action potential was used as a signal of variable frequency in order to measure the apparent membrane capacity of cardiac Purkyne fibres.2. The upstroke in Na-Tyrode can be regarded as a high frequency signal. Action potentials in Na-free, Sr-Tyrode are characterized by a very small rate of depolarization (5 V/sec) and conduction velocity (15 cm/sec) and were used as a low frequency signal.3. On changing from Na- to Sr-Tyrode the apparent membrane capacity increased by a factor of 3.77 and approached the value estimated by the square-current technique.4. Cable properties (space and time constants, internal core and membrane resistance) were found to be constant when changing from Na- to Sr-Tyrode.5. The significance of the frequency dependent character of the membrane capacity is discussed in relation to propagation and form of the action potential.
摘要
动作电位的上升支被用作可变频率信号，以测量心脏浦肯野纤维的表观膜电容。
在钠-台氏液中的上升支可被视为高频信号。无钠、锶-台氏液中的动作电位的特征是去极化速率非常小（5伏/秒）和传导速度（15厘米/秒），并被用作低频信号。
从钠-台氏液改为锶-台氏液时，表观膜电容增加了3.77倍，并接近方电流技术估计的值。
当从钠-台氏液改为锶-台氏液时，发现电缆特性（空间和时间常数、内芯和膜电阻）是恒定的。
讨论了膜电容频率依赖性特征与动作电位的传播和形态的关系。
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