Dyer R F, Peppler R D
Anat Rec. 1977 Feb;187(2):241-7. doi: 10.1002/ar.1091870209.
An experiment designed to study the effects of the copper IUD on the virgin rat uterus has revealed the presence of intracellular collagen fibrils in control uteri and in uteri that have contained a copper IUD for three months. The cells containing the collagen are found in the stroma in close proximity to the uterine epithelium. The collagen is found within membrane-bound cytoplasmic vacuoles that vary in morphology. In some cases the fibrils are tightly packed and linear, with no other material evident in the vacuole. In other examples, the fibrils are randomly arranged and the vacuoles contain a punctuate material which is characteristic of phagolysosomes. Finally, cytoplasmic vacuoles are seen which contain ill-defined debris and poorly-visualized structures that exhibit a periodicity, suggesting a terminal phase of fibril breakdown. All animals were sacrificed in metestrus, and the results indicate that intracellular collagen is present in the nulliparous rat uterus at this stage of the cycle. In addition, this phenomenon does not appear to be influenced by the presence of a copper IUD over a period of three months.
一项旨在研究铜宫内节育器对未交配大鼠子宫影响的实验发现，在对照子宫以及放置铜宫内节育器三个月的子宫中均存在细胞内胶原纤维。含有胶原的细胞存在于靠近子宫上皮的基质中。胶原存在于形态各异的膜结合细胞质空泡内。在某些情况下，纤维紧密排列且呈线性，空泡内无其他明显物质。在其他例子中，纤维随机排列，空泡内含有点状物质，这是吞噬溶酶体的特征。最后，可见含有不明确碎片和难以看清的具有周期性结构的细胞质空泡，提示纤维分解的终末阶段。所有动物均在动情后期处死，结果表明在这个周期阶段未生育大鼠子宫中存在细胞内胶原。此外，这种现象似乎不受三个月期间铜宫内节育器存在的影响。
